General Information of Drug-Metabolizing Enzyme (DME ID: DME1031)
DME Name Chloramphenicolase (chlR), Proteus penneri DME Info
UniProt ID
A0A5M4B0P0_9BACT
EC Number    EC: 2.3.1.28     (Click to Show/Hide the Complete EC Tree)
Transferase
Acyltransferase
Acyltransferase
EC: 2.3.1.28
Lineage    Species: Proteus penneri     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Morganellaceae
Genus: Proteus
Species: Proteus penneri
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Chloramphenicol Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            Mephenytoin 4-hydroxylase (CYP2C19) Click to Show/Hide the Cometabolization Info
DME ID DME0021 DME Info
Uniprot ID
CP2CJ_HUMAN
Interaction Name CYP2C19-chlR interaction [1], [2]
Description The interaction, between human Mephenytoin 4-hydroxylase and Chloramphenicolase from Proteus penneri which collectively metabolize the drug Chloramphenicol, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 The bacterial degradation of chloramphenico. Lancet. 1967 Jun 10;1(7502):1259-60.
2 Chloramphenicol is a potent inhibitor of cytochrome P450 isoforms CYP2C19 and CYP3A4 in human liver microsomes. Antimicrob Agents Chemother. 2003 Nov;47(11):3464-9.

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