Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1033)
DME Name Beta-lactamase (blaB), Edwardsiella tarda DME Info
UniProt ID
A4LA84_EDWTA
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Edwardsiella tarda     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Hafniaceae
Genus: Edwardsiella
Species: Edwardsiella tarda
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Clindamycin Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            Cytochrome P450 3A4 (CYP3A4) Click to Show/Hide the Cometabolization Info
DME ID DME0001 DME Info
Uniprot ID
CP3A4_HUMAN
Interaction Name CYP3A4-blaB interaction [1], [2]
Description The interaction, between human Cytochrome P450 3A4 and Beta-lactamase from Edwardsiella tarda which collectively metabolize the drug Clindamycin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Comparison of antimicrobial susceptibility, beta-lactamase production, plasmid analysis and serum bactericidal activity in Edwardsiella tarda, E. ictaluri and E. hoshinae. J Med Microbiol. 1993 Oct;39(4):273-81.
2 In vitro metabolism of clindamycin in human liver and intestinal microsomes. Drug Metab Dispos. 2003 Jul;31(7):878-87.

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