Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1035)
DME Name	Cardiac glycoside reductase 1 (cgr1), Eggerthella lenta	DME Info
UniProt ID	CGR1_EGGLE
EC Number	EC: 1.3.2.- (Click to Show/Hide the Complete EC Tree) Oxidoreductase CH-CH donor oxidoreductase Quinone acceptor oxidoreductase EC: 1.3.2.-
Lineage	Species: Eggerthella lenta (Click to Show/Hide the Complete Species Lineage) Kingdom: Bacteria Phylum: Actinobacteria Class: Coriobacteriia Order: Eggerthellales Family: Eggerthellaceae Genus: Eggerthella Species: Eggerthella lenta
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
Drug co-metabolism
Cometabolized drug: Digoxin		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
Cytochrome P450 3A4 (CYP3A4)		Click to Show/Hide the Cometabolization Info
DME ID	DME0001 DME Info
Uniprot ID	CP3A4_HUMAN
Interaction Name	CYP3A4-cgr1 interaction		[1], [2]
Description	The interaction, between human Cytochrome P450 3A4 and Cardiac glycoside reductase 1 from Eggerthella lenta which collectively metabolize the drug Digoxin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.

References
1	Mechanistic insight into digoxin inactivation by Eggerthella lenta augments our understanding of its pharmacokinetics. Gut Microbes. 2014 Mar-Apr;5(2):233-8.
2	Omeprazole-associated digoxin toxicity. South Med J. 2007 Apr;100(4):400-2.

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