Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1052)
DME Name Glyceraldehyde-3-phosphate dehydrogenase (gap), Lactobacillus acidophilus DME Info
UniProt ID
A0A3A9YGB0_LACAI
EC Number    EC: 1.2.1.-     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Aldehyde/oxo donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.2.1.-
Lineage    Species: Lactobacillus acidophilus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus acidophilus
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: CERC-801 Click to Show/Hide the Full List of HOSPPI:        2 HOSPPI
                            Galactose kinase (GALK1) Click to Show/Hide the Cometabolization Info
DME ID DME0417 DME Info
Uniprot ID
GALK1_HUMAN
Interaction Name GALK1-gap interaction [1], [2]
Description The interaction, between human Galactose kinase and Glyceraldehyde-3-phosphate dehydrogenase from Lactobacillus acidophilus which collectively metabolize the drug CERC-801, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Sulfotransferase 1A1 (SULT1A1) Click to Show/Hide the Cometabolization Info
DME ID DME0008 DME Info
Uniprot ID
ST1A1_HUMAN
Interaction Name SULT1A1-gap interaction [1], [4]
Description The interaction, between human Sulfotransferase 1A1 and Glyceraldehyde-3-phosphate dehydrogenase from Lactobacillus acidophilus which collectively metabolize the drug CERC-801, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
               Cometabolized drug: NA-alpha-D-glucosamine Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            Phosphoglucomutase 3 (PGM3) Click to Show/Hide the Cometabolization Info
DME ID DME0536 DME Info
Uniprot ID
AGM1_HUMAN
Interaction Name PGM3-gap interaction [1], [3]
Description The interaction, between human Phosphoglucomutase 3 and Glyceraldehyde-3-phosphate dehydrogenase from Lactobacillus acidophilus which collectively metabolize the drug NA-alpha-D-glucosamine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Cloning, expression and characterization of a mucin-binding GAPDH from Lactobacillus acidophilus. Int J Biol Macromol. 2016 Oct;91:338-46.
2 Molecular and biochemical characterization of human galactokinase and its small molecule inhibitors. Chem Biol Interact. 2010 Dec 5;188(3):376-85.
3 Functional cloning and mutational analysis of the human cDNA for phosphoacetylglucosamine mutase: identification of the amino acid residues essential for the catalysis. Biochim Biophys Acta. 2000 Jul 24;1492(2-3):369-76.
4 Sulfation of the galactose residues in the glycosaminoglycan-protein linkage region by recombinant human chondroitin 6-O-sulfotransferase-1. J Biol Chem. 2008 Oct 10;283(41):27438-43.

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