Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1052)
DME Name Glyceraldehyde-3-phosphate dehydrogenase (gap), Lactobacillus acidophilus
Synonyms Spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase; DM298_07395; DWV49_09860; FCF10_01070; GAPDH; LAC30SC_03490
Gene Name gap
UniProt ID
A0A3A9YGB0_LACAI
Gene ID
31801837
EC Number    EC: 1.2.1.-     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Aldehyde/oxo donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.2.1.-
Lineage    Species: Lactobacillus acidophilus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus acidophilus
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MTVKIGINGFGRIGRLAFRRIMDLGEKTKDIEVVAINDLTTPAMLAYLLKYDTTHGTFNH
EVSSTDDSIVVDGKKYRVYAEPQAQNIPWVKNDGVDFVLECTGFYTSKAKSQAHLDAGAK
RVLISAPAGNDLKTIVYSVNENTLTADDKIVSAASCTTNSLAPMANALDKEFGIEVATMT
TIHAYTGTQMTLDGPSRSGKEQDARAAAENIIPHTTGSAKAIGLVLPNLNGKMNGHAQRV
PVPDGSETELVSILKKKVTADEVNEAMKKYESPSFAYNGDHIVSSDVINMTAGSIFDPTQ
TMVTTAGDKQLVKTVAWYDNEYSFTCQMVRTLLHFATL
Pathway Biosynthesis of amino acids (lai01230 )
Biosynthesis of secondary metabolites (lai01110 )
Carbon metabolism (lai01200 )
Glycolysis / Gluconeogenesis (lai00010 )
Metabolic pathways (lai01100 )
Microbial metabolism in diverse environments (lai01120 )
Function This enzyme takes part in glucose metabolic process.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 3 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
AS-12141
 Drug Info Phase 3 Gaucher disease ICD11: 5C56 [1]
      Drugs in Phase 2 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
CERC-801
 Drug Info Phase 2 Glycosylation disorder ICD11: 5C54 [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          2 Drugs
Mannose
 Drug Info Investigative Discovery agent ICD: N.A. [1]
NA-alpha-D-glucosamine
 Drug Info Investigative Discovery agent ICD: N.A. [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR007411 CERC-801 Unclear Unclear - Unclear CERC-801 [1]
References
1 Cloning, expression and characterization of a mucin-binding GAPDH from Lactobacillus acidophilus. Int J Biol Macromol. 2016 Oct;91:338-46.

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