Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1054)
DME Name L-arabinose isomerase (araA), Clostridium hylemonae DME Info
UniProt ID
C0C0X3_9FIRM
EC Number    EC: 5.3.1.4     (Click to Show/Hide the Complete EC Tree)
Isomerase
Intramolecular oxidoreductase
Aldose/ketose isomerase
EC: 5.3.1.4
Lineage    Species: Clostridium hylemonae     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Lachnospiraceae
Genus: Lachnoclostridium
Species: Clostridium hylemonae
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: CERC-801 Click to Show/Hide the Full List of HOSPPI:        2 HOSPPI
                            Galactose kinase (GALK1) Click to Show/Hide the Cometabolization Info
DME ID DME0417 DME Info
Uniprot ID
GALK1_HUMAN
Interaction Name GALK1-araA interaction [1], [2]
Description The interaction, between human Galactose kinase and L-arabinose isomerase from Clostridium hylemonae which collectively metabolize the drug CERC-801, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Sulfotransferase 1A1 (SULT1A1) Click to Show/Hide the Cometabolization Info
DME ID DME0008 DME Info
Uniprot ID
ST1A1_HUMAN
Interaction Name SULT1A1-araA interaction [1], [3]
Description The interaction, between human Sulfotransferase 1A1 and L-arabinose isomerase from Clostridium hylemonae which collectively metabolize the drug CERC-801, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Biochemical properties of L-arabinose isomerase from Clostridium hylemonae to produce D-tagatose as a functional sweetener. PLoS One. 2018 Apr 23;13(4):e0196099.
2 Molecular and biochemical characterization of human galactokinase and its small molecule inhibitors. Chem Biol Interact. 2010 Dec 5;188(3):376-85.
3 Sulfation of the galactose residues in the glycosaminoglycan-protein linkage region by recombinant human chondroitin 6-O-sulfotransferase-1. J Biol Chem. 2008 Oct 10;283(41):27438-43.

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