Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1057)
DME Name Catechol-2,3-dioxygenase (caD), Bacillus pumilus DME Info
UniProt ID
A0A371SLU3_9BACI
EC Number    EC: 1.13.11.2     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen single donor oxidoreductase
Oxygen single donor oxidoreductase
EC: 1.13.11.2
Lineage    Species: Bacillus pumilus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Bacillales
Family: Bacillaceae
Genus: Bacillus
Species: Bacillus pumilus
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Gemfibrozil Click to Show/Hide the Full List of HOSPPI:        5 HOSPPI
                            Cytochrome P450 3A4 (CYP3A4) Click to Show/Hide the Cometabolization Info
DME ID DME0001 DME Info
Uniprot ID
CP3A4_HUMAN
Interaction Name CYP3A4-caD interaction [1], [2]
Description The interaction, between human Cytochrome P450 3A4 and Catechol-2,3-dioxygenase from Bacillus pumilus which collectively metabolize the drug Gemfibrozil, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            UDP-glucuronosyltransferase 1A1 (UGT1A1) Click to Show/Hide the Cometabolization Info
DME ID DME0004 DME Info
Uniprot ID
UD11_HUMAN
Interaction Name UGT1A1-caD interaction [1], [3]
Description The interaction, between human UDP-glucuronosyltransferase 1A1 and Catechol-2,3-dioxygenase from Bacillus pumilus which collectively metabolize the drug Gemfibrozil, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            UDP-glucuronosyltransferase 1A3 (UGT1A3) Click to Show/Hide the Cometabolization Info
DME ID DME0041 DME Info
Uniprot ID
UD13_HUMAN
Interaction Name UGT1A3-caD interaction [1], [4]
Description The interaction, between human UDP-glucuronosyltransferase 1A3 and Catechol-2,3-dioxygenase from Bacillus pumilus which collectively metabolize the drug Gemfibrozil, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            UDP-glucuronosyltransferase 1A9 (UGT1A9) Click to Show/Hide the Cometabolization Info
DME ID DME0042 DME Info
Uniprot ID
UD19_HUMAN
Interaction Name UGT1A9-caD interaction [1], [3]
Description The interaction, between human UDP-glucuronosyltransferase 1A9 and Catechol-2,3-dioxygenase from Bacillus pumilus which collectively metabolize the drug Gemfibrozil, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            UDP-glucuronosyltransferase 2B7 (UGT2B7) Click to Show/Hide the Cometabolization Info
DME ID DME0040 DME Info
Uniprot ID
UD2B7_HUMAN
Interaction Name UGT2B7-caD interaction [1], [3]
Description The interaction, between human UDP-glucuronosyltransferase 2B7 and Catechol-2,3-dioxygenase from Bacillus pumilus which collectively metabolize the drug Gemfibrozil, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Genomic, proteomic, and metabolite characterization of gemfibrozil-degrading organism Bacillus sp. GeD10. Environ Sci Technol. 2016 Jan 19;50(2):744-55.
2 Clinical pharmacokinetics of fibric acid derivatives (fibrates). Clin Pharmacokinet. 1998 Feb;34(2):155-62.
3 The UDP-glucuronosyltransferase 2B7 isozyme is responsible for gemfibrozil glucuronidation in the human liver. Drug Metab Dispos. 2007 Nov;35(11):2040-4.
4 Comprehensive pharmacogenomic study reveals an important role of UGT1A3 in montelukast pharmacokinetics. Clin Pharmacol Ther. 2018 Jul;104(1):158-168.

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