Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1059)
DME Name Fumarate reductase flavoprotein (frdA), Wolinella succinogenes DME Info
UniProt ID
FRDA_WOLSU
EC Number    EC: 1.3.5.4     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-CH donor oxidoreductase
Quinone acceptor oxidoreductase
EC: 1.3.5.4
Lineage    Species: Wolinella succinogenes     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Epsilonproteobacteria
Order: Campylobacterales
Family: Helicobacteraceae
Genus: Wolinella
Species: Wolinella succinogenes
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Hydroquinone Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            Cytochrome P450 3A4 (CYP3A4) Click to Show/Hide the Cometabolization Info
DME ID DME0001 DME Info
Uniprot ID
CP3A4_HUMAN
Interaction Name CYP3A4-frdA interaction [1], [2]
Description The interaction, between human Cytochrome P450 3A4 and Fumarate reductase flavoprotein from Wolinella succinogenes which collectively metabolize the drug Hydroquinone, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Wolinella succinogenes quinol:fumarate reductase and its comparison to E. coli succinate:quinone reductase. FEBS Lett. 2003 Nov 27;555(1):21-8.
2 Metabolism of (S)-5,6-difluoro-4-cyclopropylethynyl-4-trifluoromethyl-3, 4-dihydro-2(1H)-quinazolinone, a non-nucleoside reverse transcriptase inhibitor, in human liver microsomes. Metabolic activation and enzyme kinetics. Drug Metab Dispos. 2003 Jan;31(1):122-32.

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