Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1061)
DME Name Tyrosine decarboxylase (tdc), Enterococcus faecalis DME Info
UniProt ID
TYRDC_ENTFA
EC Number    EC: 4.1.1.25     (Click to Show/Hide the Complete EC Tree)
Lyases
Carbon-carbon lyase
Carboxy-lyase
EC: 4.1.1.25
Lineage    Species: Enterococcus faecalis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Enterococcaceae
Genus: Enterococcus
Species: Enterococcus faecalis
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Levodopa Click to Show/Hide the Full List of HOSPPI:        3 HOSPPI
                            Cytochrome P450 2D6 (CYP2D6) Click to Show/Hide the Cometabolization Info
DME ID DME0009 DME Info
Uniprot ID
CP2D6_HUMAN
Interaction Name CYP2D6-tdc interaction [1], [2], [3]
Description The interaction, between human Cytochrome P450 2D6 and Tyrosine decarboxylase from Enterococcus faecalis which collectively metabolize the drug Levodopa, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            DOPA decarboxylase (DDC) Click to Show/Hide the Cometabolization Info
DME ID DME0125 DME Info
Uniprot ID
DDC_HUMAN
Interaction Name DDC-tdc interaction [1], [2], [4]
Description The interaction, between human DOPA decarboxylase and Tyrosine decarboxylase from Enterococcus faecalis which collectively metabolize the drug Levodopa, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Thiopurine methyltransferase (TPMT) Click to Show/Hide the Cometabolization Info
DME ID DME0014 DME Info
Uniprot ID
TPMT_HUMAN
Interaction Name TPMT-tdc interaction [1], [2], [5]
Description The interaction, between human Thiopurine methyltransferase and Tyrosine decarboxylase from Enterococcus faecalis which collectively metabolize the drug Levodopa, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism. Science. 2019 Jun 14;364(6445). pii: eaau6323.
2 Gut bacterial tyrosine decarboxylases restrict levels of levodopa in the treatment of Parkinson's disease. Nat Commun. 2019 Jan 18;10(1):310.
3 Multiple cytochrome P450 enzymes responsible for the oxidative metabolism of the substituted (S)-3-phenylpiperidine, (S,S)-3-[3-(methylsulfonyl)phenyl]-1-propylpiperidine hydrochloride, in human liver microsomes. Drug Metab Dispos. 2002 Dec;30(12):1372-7.
4 Complexity of dopamine metabolism. Cell Commun Signal. 2013 May 17;11(1):34.
5 Reduced 3-O-methyl-dopa levels in OCD patients and their unaffected parents is associated with the low activity M158 COMT allele. Am J Med Genet B Neuropsychiatr Genet. 2010 Mar 5;153B(2):542-548.

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