Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1070)
DME Name Nitroreductase (NTR), Clostridium leptum DME Info
UniProt ID
A0A412R9E4_9FIRM
EC Number    EC: 1.5.1.39     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-NH donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.5.1.39
Lineage    Species: Clostridium leptum     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Ruminococcaceae
Genus: Clostridium
Species: Clostridium leptum
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Nitrazepam Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            Cytochrome P450 3A4 (CYP3A4) Click to Show/Hide the Cometabolization Info
DME ID DME0001 DME Info
Uniprot ID
CP3A4_HUMAN
Interaction Name CYP3A4-NTR interaction [1], [2]
Description The interaction, between human Cytochrome P450 3A4 and Nitroreductase from Clostridium leptum which collectively metabolize the drug Nitrazepam, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
               Cometabolized drug: Nitrofurantoin Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            NADPH-cytochrome P450 reductase (CPR) Click to Show/Hide the Cometabolization Info
DME ID DME0076 DME Info
Uniprot ID
NCPR_HUMAN
Interaction Name CPR-NTR interaction [3], [4]
Description The interaction, between human NADPH-cytochrome P450 reductase and Nitroreductase from Clostridium leptum which collectively metabolize the drug Nitrofurantoin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Reduction of nitrazepam by Clostridium leptum, a nitroreductase-producing bacterium isolated from the human intestinal tract. Clin Infect Dis. 1997 Sep;25 Suppl 2:S121-2.
2 Prediction of metabolic clearance using fresh human hepatocytes: comparison with cryopreserved hepatocytes and hepatic microsomes for five benzodiazepines. Xenobiotica. 2008 Apr;38(4):353-67.
3 Isolation of nitrofurantoin-resistant mutants of nitroreductase-producing Clostridium sp. strains from the human intestinal tract. Antimicrob Agents Chemother. 1998 May;42(5):1121-6.
4 Role of cytochrome P450 reductase in nitrofurantoin-induced redox cycling and cytotoxicity. Free Radic Biol Med. 2008 Mar 15;44(6):1169-79.

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