Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1077)
DME Name NADPH-dependent curcumin reductase (curA), Escherichia coli DME Info
UniProt ID
CURA_ECOLI
EC Number    EC: 1.3.1.-     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-CH donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.3.1.-
Lineage    Species: Escherichia coli     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Escherichia
Species: Escherichia coli
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: SRT-501 Click to Show/Hide the Full List of HOSPPI:        2 HOSPPI
                            Cytochrome P450 1A2 (CYP1A2) Click to Show/Hide the Cometabolization Info
DME ID DME0003 DME Info
Uniprot ID
CP1A2_HUMAN
Interaction Name CYP1A2-curA interaction [1], [2]
Description The interaction, between human Cytochrome P450 1A2 and NADPH-dependent curcumin reductase from Escherichia coli which collectively metabolize the drug SRT-501, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Sulfotransferase 1C2 (SULT1C2) Click to Show/Hide the Cometabolization Info
DME ID DME0614 DME Info
Uniprot ID
ST1C2_HUMAN
Interaction Name SULT1C2-curA interaction [1], [3]
Description The interaction, between human Sulfotransferase 1C2 and NADPH-dependent curcumin reductase from Escherichia coli which collectively metabolize the drug SRT-501, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
               Cometabolized drug: Curcumin Click to Show/Hide the Full List of HOSPPI:        4 HOSPPI
                            UDP-glucuronosyltransferase 1A1 (UGT1A1) Click to Show/Hide the Cometabolization Info
DME ID DME0004 DME Info
Uniprot ID
UD11_HUMAN
Interaction Name UGT1A1-curA interaction [1], [4]
Description The interaction, between human UDP-glucuronosyltransferase 1A1 and NADPH-dependent curcumin reductase from Escherichia coli which collectively metabolize the drug Curcumin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            UDP-glucuronosyltransferase 1A7 (UGT1A7) Click to Show/Hide the Cometabolization Info
DME ID DME0065 DME Info
Uniprot ID
UD17_HUMAN
Interaction Name UGT1A7-curA interaction [1], [4]
Description The interaction, between human UDP-glucuronosyltransferase 1A7 and NADPH-dependent curcumin reductase from Escherichia coli which collectively metabolize the drug Curcumin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            UDP-glucuronosyltransferase 1A8 (UGT1A8) Click to Show/Hide the Cometabolization Info
DME ID DME0064 DME Info
Uniprot ID
UD18_HUMAN
Interaction Name UGT1A8-curA interaction [1], [4]
Description The interaction, between human UDP-glucuronosyltransferase 1A8 and NADPH-dependent curcumin reductase from Escherichia coli which collectively metabolize the drug Curcumin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            UDP-glucuronosyltransferase 1A9 (UGT1A9) Click to Show/Hide the Cometabolization Info
DME ID DME0042 DME Info
Uniprot ID
UD19_HUMAN
Interaction Name UGT1A9-curA interaction [1], [4]
Description The interaction, between human UDP-glucuronosyltransferase 1A9 and NADPH-dependent curcumin reductase from Escherichia coli which collectively metabolize the drug Curcumin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism. Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6615-20.
2 Involvement of cytochrome P450 1A2 in the biotransformation of trans-resveratrol in human liver microsomes. Biochem Pharmacol. 2004 Aug 15;68(4):773-82.
3 Correlation of reactive oxygen species levels with resveratrol sensitivities of anaplastic thyroid cancer cells. Oxid Med Cell Longev. 2018 Jul 10;2018:6235417.
4 Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake. J Biol Chem. 2004 Jan 9;279(2):1429-41.

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