Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1088)
DME Name Hydroxybenzoate 3-monooxygenase (pobA), Pseudomonas fluorescens DME Info
UniProt ID
PHHY_PSEFL
EC Number    EC: 1.14.13.2     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
NADH/NADPH donor oxidoreductase
EC: 1.14.13.2
Lineage    Species: Pseudomonas fluorescens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Pseudomonadales
Family: Pseudomonadaceae
Genus: Pseudomonas
Species: Pseudomonas fluorescens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Tetracycline Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            Cytochrome P450 3A4 (CYP3A4) Click to Show/Hide the Cometabolization Info
DME ID DME0001 DME Info
Uniprot ID
CP3A4_HUMAN
Interaction Name CYP3A4-pobA interaction [1], [2]
Description The interaction, between human Cytochrome P450 3A4 and Hydroxybenzoate 3-monooxygenase from Pseudomonas fluorescens which collectively metabolize the drug Tetracycline, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Structural comparison of p-hydroxybenzoate hydroxylase (PobA) from Pseudomonas putida with PobA from other Pseudomonas spp. and other monooxygenases. Acta Crystallogr F Struct Biol Commun. 2019 Jul 1;75(Pt 7):507-514.
2 The In vitro hepatic metabolism of quinine in mice, rats and dogs: comparison with human liver microsomes. J Pharmacol Exp Ther. 1997 Dec;283(3):1168-76.

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