Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1092)
DME Name	Aldehyde oxidase (AOX), Clostridium sporogenes	DME Info
UniProt ID	A0A1V9IQJ2_CLOSG
EC Number	EC: 1.17.1.4 (Click to Show/Hide the Complete EC Tree) Oxidoreductase CH/CH2 oxidoreductase NAD/NADP acceptor oxidoreductase EC: 1.17.1.4
Lineage	Species: Clostridium sporogenes (Click to Show/Hide the Complete Species Lineage) Kingdom: Bacteria Phylum: Firmicutes Class: Clostridia Order: Clostridiales Family: Clostridiaceae Genus: Clostridium Species: Clostridium sporogenes
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
Drug co-metabolism
Cometabolized drug: Zonisamide		Click to Show/Hide the Full List of HOSPPI: 5 HOSPPI
Cytochrome P450 3A4 (CYP3A4)		Click to Show/Hide the Cometabolization Info
DME ID	DME0001 DME Info
Uniprot ID	CP3A4_HUMAN
Interaction Name	CYP3A4-AOX interaction		[1], [2]
Description	The interaction, between human Cytochrome P450 3A4 and Aldehyde oxidase from Clostridium sporogenes which collectively metabolize the drug Zonisamide, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
Cytochrome P450 3A5 (CYP3A5)		Click to Show/Hide the Cometabolization Info
DME ID	DME0012 DME Info
Uniprot ID	CP3A5_HUMAN
Interaction Name	CYP3A5-AOX interaction		[1], [3]
Description	The interaction, between human Cytochrome P450 3A5 and Aldehyde oxidase from Clostridium sporogenes which collectively metabolize the drug Zonisamide, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
Cytochrome P450 3A7 (CYP3A7)		Click to Show/Hide the Cometabolization Info
DME ID	DME0015 DME Info
Uniprot ID	CP3A7_HUMAN
Interaction Name	CYP3A7-AOX interaction		[1], [4]
Description	The interaction, between human Cytochrome P450 3A7 and Aldehyde oxidase from Clostridium sporogenes which collectively metabolize the drug Zonisamide, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
Mephenytoin 4-hydroxylase (CYP2C19)		Click to Show/Hide the Cometabolization Info
DME ID	DME0021 DME Info
Uniprot ID	CP2CJ_HUMAN
Interaction Name	CYP2C19-AOX interaction		[1], [5]
Description	The interaction, between human Mephenytoin 4-hydroxylase and Aldehyde oxidase from Clostridium sporogenes which collectively metabolize the drug Zonisamide, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
UDP-glucuronosyltransferase 1A1 (UGT1A1)		Click to Show/Hide the Cometabolization Info
DME ID	DME0004 DME Info
Uniprot ID	UD11_HUMAN
Interaction Name	UGT1A1-AOX interaction		[1], [6]
Description	The interaction, between human UDP-glucuronosyltransferase 1A1 and Aldehyde oxidase from Clostridium sporogenes which collectively metabolize the drug Zonisamide, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.

References
1	The role of mammalian intestinal bacteria in the reductive metabolism of zonisamide. J Pharm Pharmacol. 1997 Mar;49(3):253-6.
2	Pharmacokinetics and drug interactions with zonisamide. Epilepsia. 2007 Mar;48(3):435-41.
3	Prediction of drug-drug interactions of zonisamide metabolism in humans from in vitro data. Eur J Clin Pharmacol. 1998 Apr;54(2):177-83.
4	Differential catalytic properties in metabolism of endogenous and exogenous substrates among CYP3A enzymes expressed in COS-7 cells. Biochim Biophys Acta. 1998 May 8;1380(3):297-304.
5	Carbamazepine pharmacokinetics are not affected by zonisamide: in vitro mechanistic study and in vivo clinical study in epileptic patients. Epilepsy Res. 2004 Nov;62(1):1-11.
6	Actual and Predicted Pharmacokinetic Interactions Between Anticonvulsants and Antiretrovirals.

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