| General Information of Drug-Metabolizing Enzyme (DME ID: DME1113) |
| DME Name |
Thymidylate synthase (thyA), Lactobacillus casei
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DME Info
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| UniProt ID |
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| EC Number |
EC: 2.1.1.45 (Click to Show/Hide the Complete EC Tree)
Transferase
Methylase
Methyltransferase
EC: 2.1.1.45
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| Lineage |
Species: Lactobacillus casei (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus casei
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| Interactome |
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| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| Drug co-metabolism |
| Cometabolized drug: Deoxy-UMP |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| Thymidylate synthase (TYMS) |
Click to Show/Hide the Cometabolization Info |
| DME ID |
DME0137
DME Info
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| Uniprot ID |
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| Interaction Name |
TYMS-thyA interaction |
[1], [2] |
| Description |
The interaction, between human Thymidylate synthase and Thymidylate synthase from Lactobacillus casei which collectively metabolize the drug Deoxy-UMP, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism. |
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| References |
| 1 |
Role of the conserved tryptophan 82 of Lactobacillus casei thymidylate synthase. Chem Biol. 1995 Sep;2(9):609-14.
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| 2 |
Distribution of mutations in human thymidylate synthase yielding resistance to 5-fluorodeoxyuridine. J Biol Chem. 2002 Sep 27;277(39):36304-11.
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