Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1113)
DME Name Thymidylate synthase (thyA), Lactobacillus casei
Synonyms Bacterial dihydrofolate reductase-thymidylate synthase; dTMP synthase; BgDHFR-TS; DHFR-TS; HTS; thyA
Gene Name thyA
UniProt ID
TYSY_LACCA
EC Number    EC: 2.1.1.45     (Click to Show/Hide the Complete EC Tree)
Transferase
Methylase
Methyltransferase
EC: 2.1.1.45
Lineage    Species: Lactobacillus casei     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus casei
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MLEQPYLDLAKKVLDEGHFKPDRTHTGTYSIFGHQMRFDLSKGFPLLTTKKVPFGLIKSE
LLWFLHGDTNIRFLLQHRNHIWDEWAFEKWVKSDEYHGPDMTDFGHRSQKDPEFAAVYHE
EMAKFDDRVLHDDAFAAKYGDLGLVYGSQWRAWHTSKGDTIDQLGDVIEQIKTHPYSRRL
IVSAWNPEDVPTMALPPCHTLYQFYVNDGKLSLQLYQRSADIFLGVPFNIASYALLTHLV
AHECGLEVGEFIHTFGDAHLYVNHLDQIKEQLSRTPRPAPTLQLNPDKHDIFDFDMKDIK
LLNYDPYPAIKAPVAV
Structure
1BO7 ; 1BO8 ; 1BP0 ; 1BP6 ; 1BPJ ; 1JMF ; 1JMG ; 1JMH ; 1JMI ; 1LCA ; 1LCB ; 1LCE ; 1NJA ; 1NJB ; 1NJC ; 1TDB ; 1TDC ; 1THY ; 1TSL ; 1TSM ; 1TSV ; 1TSW ; 1TSX ; 1TSY ; 1TSZ ; 1TVU ; 1TVV ; 1TVW ; 1VZA ; 1VZB ; 1VZC ; 1VZD ; 1VZE ; 2G86 ; 2G89 ; 2G8A ; 2G8D ; 2TDD ; 2TDM ; 3BNZ ; 3BYX ; 3BZ0 ; 3C06 ; 3C0A ; 3IJZ ; 3IK0 ; 3IK1 ; 4TMS
Function This enzyme catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Deoxy-UMP
 Drug Info Investigative Discovery agent ICD: N.A. [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR005333 Deoxy-UMP 2'-deoxythymidine-5'-monophosphate (dTMP) Conjugation - Methylationn Deoxy-UMP [1]
MR005334 Deoxy-UMP 7,8-dihydrofolate (H2folate) Unclear - Unclear Deoxy-UMP [1]
References
1 Role of the conserved tryptophan 82 of Lactobacillus casei thymidylate synthase. Chem Biol. 1995 Sep;2(9):609-14.

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