Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1116)
DME Name D-Lactate dehydrogenase (ldhA), Megasphaera elsdenii DME Info
UniProt ID
A0A1C7BXR3_PSEAI
EC Number    EC: 1.1.1.28     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.28
Lineage    Species: Megasphaera elsdenii     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Negativicutes
Order: Veillonellales
Family: Veillonellaceae
Genus: Megasphaera
Species: Megasphaera elsdenii
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: D-glucose Click to Show/Hide the Full List of HOSPPI:        2 HOSPPI
                            ADP-dependent glucokinase (ADPGK) Click to Show/Hide the Cometabolization Info
DME ID DME0475 DME Info
Uniprot ID
ADPGK_HUMAN
Interaction Name ADPGK-ldhA interaction [1], [2], [3]
Description The interaction, between human ADP-dependent glucokinase and D-Lactate dehydrogenase from Megasphaera elsdenii which collectively metabolize the drug D-glucose, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Brain form hexokinase (HK1) Click to Show/Hide the Cometabolization Info
DME ID DME0476 DME Info
Uniprot ID
HXK1_HUMAN
Interaction Name HK1-ldhA interaction [1], [2], [4]
Description The interaction, between human Brain form hexokinase and D-Lactate dehydrogenase from Megasphaera elsdenii which collectively metabolize the drug D-glucose, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Presence of lactate dehydrogenase and lactate racemase in Megasphaera elsdenii grown on glucose or lactate. Appl Environ Microbiol. 1993 Jan;59(1):255-9.
2 hole-Genome sequence of a Megasphaera elsdenii strain isolated from the gut of a healthy Indian adult subject. Genome Announc. 2017 Oct 19;5(42):e01033-17.
3 The Structural and functional characterization of mammalian ADP-dependent glucokinase. J Biol Chem. 2016 Feb 19;291(8):3694-704.
4 Nonaggregating mutant of recombinant human hexokinase I exhibits wild-type kinetics and rod-like conformations in solution. Biochemistry. 1999 Jun 29;38(26):8359-66.

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