Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1133)
DME Name Cellobiose 2-epimerase (CE), Eubacterium cellulosolvens DME Info
UniProt ID
CEEP_EUBCE
EC Number    EC: 5.1.3.11     (Click to Show/Hide the Complete EC Tree)
Isomerase
Racemase/epimerase
Carbohydrate racemase/epimerase
EC: 5.1.3.11
Lineage    Species: Eubacterium cellulosolvens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Eubacteriaceae
Genus: Eubacterium
Species: Eubacterium cellulosolvens
Subspecies: Eubacterium cellulosolvens NE13
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: M-7403 Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            Sucrase-isomaltase intestinal (SI) Click to Show/Hide the Cometabolization Info
DME ID DME0457 DME Info
Uniprot ID
SUIS_HUMAN
Interaction Name SI-CE interaction [1], [2]
Description The interaction, between human Sucrase-isomaltase intestinal and Cellobiose 2-epimerase from Eubacterium cellulosolvens which collectively metabolize the drug M-7403, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Cloning and sequencing of the gene for cellobiose 2-epimerase from a ruminal strain of Eubacterium cellulosolvens. FEMS Microbiol Lett. 2008 Oct;287(1):34-40.
2 Structural basis for substrate selectivity in human maltase-glucoamylase and sucrase-isomaltase N-terminal domains. J Biol Chem. 2010 Jun 4;285(23):17763-70.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.