Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1196)
DME Name Cytidine deaminase (cdd), Mycoplasma hyorhinis DME Info
UniProt ID
E0TLJ6_MYCHH
EC Number    EC: 3.5.4.5     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amidine hydrolase
EC: 3.5.4.5
Lineage    Species: Mycoplasma hyorhinis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Tenericutes
Class: Mollicutes
Order: Mycoplasmatales
Family: Mycoplasmataceae
Genus: Mycoplasma
Species: Mycoplasma hyorhinis
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Gemcitabine Click to Show/Hide the Full List of HOSPPI:        2 HOSPPI
                            Cytidine aminohydrolase (CDA) Click to Show/Hide the Cometabolization Info
DME ID DME0080 DME Info
Uniprot ID
CDD_HUMAN
Interaction Name CDA-cdd interaction [1], [2]
Description The interaction, between human Cytidine aminohydrolase and Cytidine deaminase from Mycoplasma hyorhinis which collectively metabolize the drug Gemcitabine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Uridine/cytidine monophosphate kinase (UMPK) Click to Show/Hide the Cometabolization Info
DME ID DME0456 DME Info
Uniprot ID
KCY_HUMAN
Interaction Name UMPK-cdd interaction [1], [7]
Description The interaction, between human Uridine/cytidine monophosphate kinase and Cytidine deaminase from Mycoplasma hyorhinis which collectively metabolize the drug Gemcitabine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
               Cometabolized drug: Azacitidine Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            Cytidine aminohydrolase (CDA) Click to Show/Hide the Cometabolization Info
DME ID DME0080 DME Info
Uniprot ID
CDD_HUMAN
Interaction Name CDA-cdd interaction [1], [3]
Description The interaction, between human Cytidine aminohydrolase and Cytidine deaminase from Mycoplasma hyorhinis which collectively metabolize the drug Azacitidine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
               Cometabolized drug: Cytarabine Click to Show/Hide the Full List of HOSPPI:        4 HOSPPI
                            Cytidine aminohydrolase (CDA) Click to Show/Hide the Cometabolization Info
DME ID DME0080 DME Info
Uniprot ID
CDD_HUMAN
Interaction Name CDA-cdd interaction [1], [4]
Description The interaction, between human Cytidine aminohydrolase and Cytidine deaminase from Mycoplasma hyorhinis which collectively metabolize the drug Cytarabine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A4 (CYP3A4) Click to Show/Hide the Cometabolization Info
DME ID DME0001 DME Info
Uniprot ID
CP3A4_HUMAN
Interaction Name CYP3A4-cdd interaction [1], [6]
Description The interaction, between human Cytochrome P450 3A4 and Cytidine deaminase from Mycoplasma hyorhinis which collectively metabolize the drug Cytarabine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Deoxycytidylate deaminase (DCTD) Click to Show/Hide the Cometabolization Info
DME ID DME0112 DME Info
Uniprot ID
DCTD_HUMAN
Interaction Name DCTD-cdd interaction [1], [4]
Description The interaction, between human Deoxycytidylate deaminase and Cytidine deaminase from Mycoplasma hyorhinis which collectively metabolize the drug Cytarabine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Ecto-5'-nucleotidase (NT5E) Click to Show/Hide the Cometabolization Info
DME ID DME0111 DME Info
Uniprot ID
5NTD_HUMAN
Interaction Name NT5E-cdd interaction [1], [4]
Description The interaction, between human Ecto-5'-nucleotidase and Cytidine deaminase from Mycoplasma hyorhinis which collectively metabolize the drug Cytarabine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
               Cometabolized drug: Decitabine Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            Cytidine aminohydrolase (CDA) Click to Show/Hide the Cometabolization Info
DME ID DME0080 DME Info
Uniprot ID
CDD_HUMAN
Interaction Name CDA-cdd interaction [1], [5]
Description The interaction, between human Cytidine aminohydrolase and Cytidine deaminase from Mycoplasma hyorhinis which collectively metabolize the drug Decitabine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Mycoplasma hyorhinis-encoded cytidine deaminase efficiently inactivates cytosine-based anticancer drugs. FEBS Open Bio. 2015 Aug 3;5:634-9.
2 Equilibrative nucleoside transporter 1 genotype, cytidine deaminase activity and age predict gemcitabine plasma clearance in patients with solid tumours. Br J Clin Pharmacol. 2011 Mar;71(3):437-44.
3 A pilot pharmacokinetic study of oral azacitidine. Leukemia. 2008 Sep;22(9):1680-4.
4 Genetic factors influencing cytarabine therapy. Pharmacogenomics. 2009 Oct;10(10):1657-74.
5 Tracking decitabine incorporation into malignant myeloid cell DNA in vitro and in vivo by LC-MS/MS with enzymatic digestion. Sci Rep. 2019 Mar 14;9(1):4558.
6 Synthesis and characterization of a novel liver-targeted prodrug of cytosine-1-beta-D-arabinofuranoside monophosphate for the treatment of hepatocellular carcinoma. J Med Chem. 2006 Dec 28;49(26):7711-20.
7 Gemcitabine pharmacogenomics: deoxycytidine kinase and cytidylate kinase gene resequencing and functional genomics. Drug Metab Dispos. 2008 Sep;36(9):1951-9.

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