Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1238)
DME Name Ribosomal 23S RNA methyltransferase Erm (erm), Corynebacterium jeikeium DME Info
UniProt ID
A0A381KDL2_CORJE
EC Number    EC: 2.1.1.182     (Click to Show/Hide the Complete EC Tree)
Transferase
Methylase
Methyltransferase
EC: 2.1.1.182
Lineage    Species: Corynebacterium jeikeium     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Corynebacteriales
Family: Corynebacteriaceae
Genus: Corynebacterium
Species: Corynebacterium jeikeium
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Tacrolimus Click to Show/Hide the Full List of HOSPPI:        3 HOSPPI
                            Cytochrome P450 3A4 (CYP3A4) Click to Show/Hide the Cometabolization Info
DME ID DME0001 DME Info
Uniprot ID
CP3A4_HUMAN
Interaction Name CYP3A4-erm interaction [1], [2]
Description The interaction, between human Cytochrome P450 3A4 and Ribosomal 23S RNA methyltransferase Erm from Corynebacterium jeikeium which collectively metabolize the drug Tacrolimus, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A5 (CYP3A5) Click to Show/Hide the Cometabolization Info
DME ID DME0012 DME Info
Uniprot ID
CP3A5_HUMAN
Interaction Name CYP3A5-erm interaction [1], [3]
Description The interaction, between human Cytochrome P450 3A5 and Ribosomal 23S RNA methyltransferase Erm from Corynebacterium jeikeium which collectively metabolize the drug Tacrolimus, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            NADPH-cytochrome P450 reductase (CPR) Click to Show/Hide the Cometabolization Info
DME ID DME0076 DME Info
Uniprot ID
NCPR_HUMAN
Interaction Name CPR-erm interaction [1], [4]
Description The interaction, between human NADPH-cytochrome P450 reductase and Ribosomal 23S RNA methyltransferase Erm from Corynebacterium jeikeium which collectively metabolize the drug Tacrolimus, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 High frequency of macrolide resistance mechanisms in clinical isolates of Corynebacterium species. Microb Drug Resist. 2010 Dec;16(4):273-7.
2 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
3 Tacrolimus pharmacokinetics and pharmacogenetics: influence of adenosine triphosphate-binding cassette B1 (ABCB1) and cytochrome (CYP) 3A polymorphisms. Fundam Clin Pharmacol. 2007 Aug;21(4):427-35.
4 Polymorphisms in cytochrome P450 oxidoreductase and its effect on drug metabolism and efficacy. Pharmacogenet Genomics. 2017 Sep;27(9):337-346.

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