Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1243)
DME Name	NADPH-dependent nitroreductase (nfrA1), Bacillus subtilis	DME Info
UniProt ID	NFRA1_BACSU
EC Number	EC: 1.5.1.38 (Click to Show/Hide the Complete EC Tree) Oxidoreductase CH-NH donor oxidoreductase NAD/NADP acceptor oxidoreductase EC: 1.5.1.38
Lineage	Species: Bacillus subtilis (Click to Show/Hide the Complete Species Lineage) Kingdom: Bacteria Phylum: Firmicutes Class: Bacilli Order: Bacillales Family: Bacillaceae Genus: Bacillus Species: Bacillus subtilis
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
Drug co-metabolism
Cometabolized drug: Riboflavin		Click to Show/Hide the Full List of HOSPPI: 7 HOSPPI
Acid phosphatase-like protein 1 (ACP6)		Click to Show/Hide the Cometabolization Info
DME ID	DME0231 DME Info
Uniprot ID	PPA6_HUMAN
Interaction Name	ACP6-nfrA1 interaction		[1], [2]
Description	The interaction, between human Acid phosphatase-like protein 1 and NADPH-dependent nitroreductase from Bacillus subtilis which collectively metabolize the drug Riboflavin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
Cytochrome P450 1A1 (CYP1A1)		Click to Show/Hide the Cometabolization Info
DME ID	DME0006 DME Info
Uniprot ID	CP1A1_HUMAN
Interaction Name	CYP1A1-nfrA1 interaction		[1], [3]
Description	The interaction, between human Cytochrome P450 1A1 and NADPH-dependent nitroreductase from Bacillus subtilis which collectively metabolize the drug Riboflavin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
Eosinophil peroxidase (EPX)		Click to Show/Hide the Cometabolization Info
DME ID	DME0244 DME Info
Uniprot ID	PERE_HUMAN
Interaction Name	EPX-nfrA1 interaction		[1], [2]
Description	The interaction, between human Eosinophil peroxidase and NADPH-dependent nitroreductase from Bacillus subtilis which collectively metabolize the drug Riboflavin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
Prostatic acid phosphatase (ACP3)		Click to Show/Hide the Cometabolization Info
DME ID	DME0232 DME Info
Uniprot ID	PPAP_HUMAN
Interaction Name	ACP3-nfrA1 interaction		[1], [2]
Description	The interaction, between human Prostatic acid phosphatase and NADPH-dependent nitroreductase from Bacillus subtilis which collectively metabolize the drug Riboflavin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
Tartrate-resistant acid ATPase (ACP5)		Click to Show/Hide the Cometabolization Info
DME ID	DME0230 DME Info
Uniprot ID	PPA5_HUMAN
Interaction Name	ACP5-nfrA1 interaction		[1], [2]
Description	The interaction, between human Tartrate-resistant acid ATPase and NADPH-dependent nitroreductase from Bacillus subtilis which collectively metabolize the drug Riboflavin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
Testicular acid phosphatase (ACP4)		Click to Show/Hide the Cometabolization Info
DME ID	DME0229 DME Info
Uniprot ID	PPAT_HUMAN
Interaction Name	ACP4-nfrA1 interaction		[1], [2]
Description	The interaction, between human Testicular acid phosphatase and NADPH-dependent nitroreductase from Bacillus subtilis which collectively metabolize the drug Riboflavin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
Xylosyl phosphatase (PXYLP1)		Click to Show/Hide the Cometabolization Info
DME ID	DME0250 DME Info
Uniprot ID	PXYP1_HUMAN
Interaction Name	PXYLP1-nfrA1 interaction		[1], [2]
Description	The interaction, between human Xylosyl phosphatase and NADPH-dependent nitroreductase from Bacillus subtilis which collectively metabolize the drug Riboflavin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
Cometabolized drug: Nitrofural		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
Cytochrome P450 2D6 (CYP2D6)		Click to Show/Hide the Cometabolization Info
DME ID	DME0009 DME Info
Uniprot ID	CP2D6_HUMAN
Interaction Name	CYP2D6-nfrA1 interaction		[1], [4], [5]
Description	The interaction, between human Cytochrome P450 2D6 and NADPH-dependent nitroreductase from Bacillus subtilis which collectively metabolize the drug Nitrofural, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
Cometabolized drug: Nitrofurantoin		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
NADPH-cytochrome P450 reductase (CPR)		Click to Show/Hide the Cometabolization Info
DME ID	DME0076 DME Info
Uniprot ID	NCPR_HUMAN
Interaction Name	CPR-nfrA1 interaction		[1], [4], [6]
Description	The interaction, between human NADPH-cytochrome P450 reductase and NADPH-dependent nitroreductase from Bacillus subtilis which collectively metabolize the drug Nitrofurantoin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.

References
1	Conversion of NfsA, the major Escherichia coli nitroreductase, to a flavin reductase with an activity similar to that of Frp, a flavin reductase in Vibrio harveyi, by a single amino acid substitution. J Bacteriol. 1998 Jan;180(2):422-5.
2	An atlas of human metabolism. Sci Signal. 2020 Mar 24;13(624). pii: eaaz1482. (Reaction HMR_6507)
3	Disruption of endogenous regulator homeostasis underlies the mechanism of rat CYP1A1 mRNA induction by metyrapone. Biochem J. 1998 Apr 1;331 ( Pt 1):273-81.
4	Bacillus subtilis isolated from the human gastrointestinal tract. Res Microbiol. 2009 Mar;160(2):134-43.
5	Nefazodone pharmacokinetics in depressed children and adolescents. J Am Acad Child Adolesc Psychiatry. 2000 Aug;39(8):1008-16.
6	Role of cytochrome P450 reductase in nitrofurantoin-induced redox cycling and cytotoxicity. Free Radic Biol Med. 2008 Mar 15;44(6):1169-79.

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