Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1245)
DME Name Nitroreductase (NTR), Clostridium perfringens DME Info
UniProt ID
B1R7B9_CLOPF
EC Number    EC: 1.5.1.39     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-NH donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.5.1.39
Lineage    Species: Clostridium perfringens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Clostridiaceae
Genus: Clostridium
Species: Clostridium perfringens
Subspecies: Clostridium perfringens B str. ATCC 3626
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Metronidazole Click to Show/Hide the Full List of HOSPPI:        6 HOSPPI
                            Cytochrome P450 2A6 (CYP2A6) Click to Show/Hide the Cometabolization Info
DME ID DME0005 DME Info
Uniprot ID
CP2A6_HUMAN
Interaction Name CYP2A6-NTR interaction [1], [2]
Description The interaction, between human Cytochrome P450 2A6 and Nitroreductase from Clostridium perfringens which collectively metabolize the drug Metronidazole, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2C9 (CYP2C9) Click to Show/Hide the Cometabolization Info
DME ID DME0019 DME Info
Uniprot ID
CP2C9_HUMAN
Interaction Name CYP2C9-NTR interaction [1], [3]
Description The interaction, between human Cytochrome P450 2C9 and Nitroreductase from Clostridium perfringens which collectively metabolize the drug Metronidazole, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A4 (CYP3A4) Click to Show/Hide the Cometabolization Info
DME ID DME0001 DME Info
Uniprot ID
CP3A4_HUMAN
Interaction Name CYP3A4-NTR interaction [1], [4]
Description The interaction, between human Cytochrome P450 3A4 and Nitroreductase from Clostridium perfringens which collectively metabolize the drug Metronidazole, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A5 (CYP3A5) Click to Show/Hide the Cometabolization Info
DME ID DME0012 DME Info
Uniprot ID
CP3A5_HUMAN
Interaction Name CYP3A5-NTR interaction [1], [2]
Description The interaction, between human Cytochrome P450 3A5 and Nitroreductase from Clostridium perfringens which collectively metabolize the drug Metronidazole, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A7 (CYP3A7) Click to Show/Hide the Cometabolization Info
DME ID DME0015 DME Info
Uniprot ID
CP3A7_HUMAN
Interaction Name CYP3A7-NTR interaction [1], [2]
Description The interaction, between human Cytochrome P450 3A7 and Nitroreductase from Clostridium perfringens which collectively metabolize the drug Metronidazole, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            UDP-glucuronosyltransferase 1A1 (UGT1A1) Click to Show/Hide the Cometabolization Info
DME ID DME0004 DME Info
Uniprot ID
UD11_HUMAN
Interaction Name UGT1A1-NTR interaction [1], [7]
Description The interaction, between human UDP-glucuronosyltransferase 1A1 and Nitroreductase from Clostridium perfringens which collectively metabolize the drug Metronidazole, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
               Cometabolized drug: Nitrofurantoin Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            NADPH-cytochrome P450 reductase (CPR) Click to Show/Hide the Cometabolization Info
DME ID DME0076 DME Info
Uniprot ID
NCPR_HUMAN
Interaction Name CPR-NTR interaction [5], [6]
Description The interaction, between human NADPH-cytochrome P450 reductase and Nitroreductase from Clostridium perfringens which collectively metabolize the drug Nitrofurantoin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Acetamide--a metabolite of metronidazole formed by the intestinal flora. Biochem Pharmacol. 1979 Dec 15;28(24):3611-5.
2 The role of human cytochrome P450 enzymes in the formation of 2-hydroxymetronidazole: CYP2A6 is the high affinity (low Km) catalyst. Drug Metab Dispos. 2013 Sep;41(9):1686-94.
3 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
4 Does metronidazole interact with CYP3A substrates by inhibiting their metabolism through this metabolic pathway? Or should other mechanisms be considered? Ann Pharmacother. 2007 Apr;41(4):653-8.
5 Isolation of nitrofurantoin-resistant mutants of nitroreductase-producing Clostridium sp. strains from the human intestinal tract. Antimicrob Agents Chemother. 1998 May;42(5):1121-6.
6 Role of cytochrome P450 reductase in nitrofurantoin-induced redox cycling and cytotoxicity. Free Radic Biol Med. 2008 Mar 15;44(6):1169-79.
7 Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios. Drug Metab Dispos. 2004 Nov;32(11):1201-8.

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