General Information of Drug-Metabolizing Enzyme (DME ID: DME1299)
DME Name Alpha-glucosidase (aglA), Lactobacillus paracasei DME Info
UniProt ID
PAGL1_LACP3
EC Number    EC: 3.2.1.20     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.20
Lineage    Species: Lactobacillus paracasei     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus paracasei
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: D-glucose Click to Show/Hide the Full List of HOSPPI:        2 HOSPPI
                            ADP-dependent glucokinase (ADPGK) Click to Show/Hide the Cometabolization Info
DME ID DME0475 DME Info
Uniprot ID
ADPGK_HUMAN
Interaction Name ADPGK-aglA interaction [1], [2]
Description The interaction, between human ADP-dependent glucokinase and Alpha-glucosidase from Lactobacillus paracasei which collectively metabolize the drug D-glucose, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Brain form hexokinase (HK1) Click to Show/Hide the Cometabolization Info
DME ID DME0476 DME Info
Uniprot ID
HXK1_HUMAN
Interaction Name HK1-aglA interaction [1], [3]
Description The interaction, between human Brain form hexokinase and Alpha-glucosidase from Lactobacillus paracasei which collectively metabolize the drug D-glucose, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Administration of Lactobacillus paracasei ameliorates type 2 diabetes in mice. Food Funct. 2018 Jul 17;9(7):3630-3639.
2 The Structural and functional characterization of mammalian ADP-dependent glucokinase. J Biol Chem. 2016 Feb 19;291(8):3694-704.
3 Nonaggregating mutant of recombinant human hexokinase I exhibits wild-type kinetics and rod-like conformations in solution. Biochemistry. 1999 Jun 29;38(26):8359-66.

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