Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1301)
DME Name Catalase-peroxidase (katG), Synechococcus elongatus DME Info
UniProt ID
KATG_SYNE7
EC Number    EC: 1.11.1.21     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Peroxidase
Peroxidase
EC: 1.11.1.21
Lineage    Species: Synechococcus elongatus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Cyanobacteria
Class: Synechococcales
Order: Synechococcales
Family: Synechococcaceae
Genus: Synechococcus
Species: Synechococcus elongatus
Subspecies: Synechococcus elongatus PCC 7942 = FACHB-805
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Isoniazid Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            Cytochrome P450 2E1 (CYP2E1) Click to Show/Hide the Cometabolization Info
DME ID DME0013 DME Info
Uniprot ID
CP2E1_HUMAN
Interaction Name CYP2E1-katG interaction [1], [2]
Description The interaction, between human Cytochrome P450 2E1 and Catalase-peroxidase from Synechococcus elongatus which collectively metabolize the drug Isoniazid, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Crystal structure of the catalase-peroxidase KatG W78F mutant from Synechococcus elongatus PCC7942 in complex with the antitubercular pro-drug isoniazid. FEBS Lett. 2015 Jan 2;589(1):131-7.
2 Inhibition of CYP2E1 catalytic activity in vitro by S-adenosyl-L-methionine. Biochem Pharmacol. 2005 Apr 1;69(7):1081-93.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.