Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1301)
DME Name Catalase-peroxidase (katG), Synechococcus elongatus
Synonyms Peroxidase/catalase; Catalase peroxidase; katG; CP; Synpcc7942_1656
Gene Name katG
UniProt ID
KATG_SYNE7
EC Number    EC: 1.11.1.21     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Peroxidase
Peroxidase
EC: 1.11.1.21
Lineage    Species: Synechococcus elongatus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Cyanobacteria
Class: Synechococcales
Order: Synechococcales
Family: Synechococcaceae
Genus: Synechococcus
Species: Synechococcus elongatus
Subspecies: Synechococcus elongatus PCC 7942 = FACHB-805
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human lung.
Sequence
MTATQGKCPVMHGGATTVNISTAEWWPKALNLDILSQHDRKTNPMGPDFNYQEEVKKLDV
AALKQDLQALMTDSQDWWPADWGHYGGLMIRLTWHAAGTYRIADGRGGAGTGNQRFAPLN
SWPDNTNLDKARRLLWPIKQKYGNKLSWADLIAYAGTIAYESMGLKTFGFAFGREDIWHP
EKDIYWGPEKEWVPPSTNPNSRYTGDRELENPLAAVTMGLIYVNPEGVDGNPDPLKTAHD
VRVTFARMAMNDEETVALTAGGHTVGKCHGNGNAALLGPEPEGADVEDQGLGWINKTQSG
IGRNAVTSGLEGAWTPHPTQWDNGYFRMLLNYDWELKKSPAGAWQWEPINPREEDLPVDV
EDPSIRRNLVMTDADMAMKMDPEYRKISERFYQDPAYFADVFARAWFKLTHRDMGPKARY
IGPDVPQEDLIWQDPIPAGNRNYDVQAVKDRIAASGLSISELVSTAWDSARTYRNSDKRG
GANGARIRLAPQKDWEGNEPDRLAKVLAVLEGIAAATGASVADVIVLAGNVGVEQAARAA
GVEIVLPFAPGRGDATAEQTDTESFAVLEPIHDGYRNWLKQDYAATPEELLLDRTQLLGL
TAPEMTVLIGGLRVLGTNHGGTKHGVFTDREGVLTNDFFVNLTDMNYLWKPAGKNLYEIC
DRKTNQVKWTATRVDLVFGSNSILRAYSELYAQDDNKEKFVRDFVAAWTKVMNADRFDLD
Structure
1UB2 ; 3WNU ; 3WXO ; 3X16 ; 4PAE
Pathway Biosynthesis of secondary metabolites (syf01110 )
Metabolic pathways (syf01100 )
Phenylalanine metabolism (syf00360 )
Tryptophan metabolism (syf00380 )
Function This enzyme is with both catalase and broad-spectrum peroxidase activity.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Isoniazid
 Drug Info Approved Pulmonary tuberculosis ICD11: 1B10 [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR002580 Calcium carbimide N-hydroxycynamide Oxidation - N-Hydroxylation Calcium carbimide [2]
References
1 Crystal structure of the catalase-peroxidase KatG W78F mutant from Synechococcus elongatus PCC7942 in complex with the antitubercular pro-drug isoniazid. FEBS Lett. 2015 Jan 2;589(1):131-7.
2 DrugBank(Pharmacology-Metabolism)Calcium carbimide

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