Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1317)
DME Name Alcohol dehydrogenase (ADH), Lactobacillus reuteri DME Info
UniProt ID
A4L2V0_LACRE
EC Number    EC: 1.1.1.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.1
Lineage    Species: Lactobacillus reuteri     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus reuteri
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: D-glucose Click to Show/Hide the Full List of HOSPPI:        2 HOSPPI
                            ADP-dependent glucokinase (ADPGK) Click to Show/Hide the Cometabolization Info
DME ID DME0475 DME Info
Uniprot ID
ADPGK_HUMAN
Interaction Name ADPGK-ADH interaction [1], [2], [3]
Description The interaction, between human ADP-dependent glucokinase and Alcohol dehydrogenase from Lactobacillus reuteri which collectively metabolize the drug D-glucose, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Brain form hexokinase (HK1) Click to Show/Hide the Cometabolization Info
DME ID DME0476 DME Info
Uniprot ID
HXK1_HUMAN
Interaction Name HK1-ADH interaction [1], [2], [4]
Description The interaction, between human Brain form hexokinase and Alcohol dehydrogenase from Lactobacillus reuteri which collectively metabolize the drug D-glucose, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 1,3-Propanediol:NAD+ oxidoreductases of Lactobacillus brevis and Lactobacillus buchneri. Appl Environ Microbiol. 1992 Jun;58(6):2005-10.
2 Aciduric strains of Lactobacillus reuteri and Lactobacillus rhamnosus, isolated from human feces, have strong adhesion and aggregation properties. Probiotics Antimicrob Proteins. 2018 Mar;10(1):89-97.
3 The Structural and functional characterization of mammalian ADP-dependent glucokinase. J Biol Chem. 2016 Feb 19;291(8):3694-704.
4 Nonaggregating mutant of recombinant human hexokinase I exhibits wild-type kinetics and rod-like conformations in solution. Biochemistry. 1999 Jun 29;38(26):8359-66.

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