Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1345)
DME Name Azoreductase (azoR), Enterococcus faecium DME Info
UniProt ID
A0A132Z973_ENTFC
EC Number    EC: 1.7.1.6     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Cytochrome acceptor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.7.1.6
Lineage    Species: Enterococcus faecium     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Enterococcaceae
Genus: Enterococcus
Species: Enterococcus faecium
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Sulfasalazine Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            Cytochrome P450 3A5 (CYP3A5) Click to Show/Hide the Cometabolization Info
DME ID DME0012 DME Info
Uniprot ID
CP3A5_HUMAN
Interaction Name CYP3A5-azoR interaction [1], [2], [3]
Description The interaction, between human Cytochrome P450 3A5 and Azoreductase from Enterococcus faecium which collectively metabolize the drug Sulfasalazine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 The influence of probiotic treatment on sulfasalazine metabolism in rat. Xenobiotica. 2012 Aug;42(8):791-7.
2 Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31.
3 Urinary 6 beta-hydroxycortisol excretion in rheumatoid arthritis. Br J Rheumatol. 1997 Jan;36(1):54-8.

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