Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1345)
DME Name Azoreductase (azoR), Enterococcus faecium
Synonyms Azo-dye reductase; FMN-dependent NADH-azo compound oxidoreductase; FMN-dependent NADH-azoreductase; azoR; A5810_000531; AS238_04965; B1P95_03410; BU183_03850; BU187_02260; BU190_11865; BU192_09835; BXT96_08720; CQR37_06980; CUM68_06655; CUN04_07390; DJ550_05610; DKP91_06820; DRZ84_07550; DTPHA_1403160; DTPHA_601027; EB63_02313; EWH22_12905; F6439_02410; F6440_11520; NCTC13923_00920; acpH
Gene Name acpH
UniProt ID
A0A132Z973_ENTFC
EC Number    EC: 1.7.1.6     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Cytochrome acceptor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.7.1.6
Lineage    Species: Enterococcus faecium     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Enterococcaceae
Genus: Enterococcus
Species: Enterococcus faecium
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MASVLVVKGHPLTAEESRTVKALTSFLTSYKENHPDDEVTVLELYRDDIPEIDEELLSGW
EALRAGAEFTSLSESQQQKIARFNELTDQFLAADKIVIANALWNLNIPTKLKAWFDTVNV
AGKTFRYTENGPEGLVTGKKALHIQSNGGVYNGQDFASQYVKGILNFVGIDQVDQLFIEG
IDYDPDRADELMQNALDKAAALGKSF
Function This enzyme catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. And it requires NADH, but not NADPH, as an electron donor for its activity.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Sulfasalazine
 Drug Info Approved Rheumatoid arthritis ICD11: FA20 [1], [2]
References
1 The influence of probiotic treatment on sulfasalazine metabolism in rat. Xenobiotica. 2012 Aug;42(8):791-7.
2 Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31.

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