Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME1473) | |||||
|---|---|---|---|---|---|
| DME Name | Azoreductase (azoR), Bacteroides fragilis | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 1.7.1.6 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Bacteroides fragilis (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| Drug co-metabolism | |||||
| Cometabolized drug: Sulfasalazine | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| Cytochrome P450 3A5 (CYP3A5) | Click to Show/Hide the Cometabolization Info | ||||
| DME ID | DME0012 DME Info | ||||
| Uniprot ID | |||||
| Interaction Name | CYP3A5-azoR interaction | [1], [2] | |||
| Description | The interaction, between human Cytochrome P450 3A5 and Azoreductase from Bacteroides fragilis which collectively metabolize the drug Sulfasalazine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism. | ||||
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