Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1473)
DME Name Azoreductase (azoR), Bacteroides fragilis
Synonyms Azo-dye reductase; FMN-dependent NADH-azo compound oxidoreductase; FMN-dependent NADH-azoreductase; azoR; BSIG_4687; Btheta7330_01816
Gene Name azoR
UniProt ID
A0A0P0ETC6_BACT4
EC Number    EC: 1.7.1.6     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Cytochrome acceptor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.7.1.6
Lineage    Species: Bacteroides fragilis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Bacteroidaceae
Genus: Bacteroides
Species: Bacteroides fragilis
Subspecies: Bacteroides fragilis str. 3397 T10
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MDRKGFLKSTMIATGSLLLGGAGICRFLNDKEPADGPFPRTIEKIHCGNMKKVLVIMSAG
TKLGNTDRLTDAYIKGLVERGHSVTKVYLGSMRIEGCRGCGVCQRLAHQCAVRDGMQDIY
PLFAECDTVVMASPLYFWTITSQLKAFIDRLYAISADDKYPQKDTVLLMTAGDDNENTFD
QPKQYFRLLSQALGWNEVGIYCAGGCTGCEKLARQIDKVHLENVYKMGLEL
Function This enzyme catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Sulfasalazine
 Drug Info Approved Rheumatoid arthritis ICD11: FA20 [1]
References
1 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.

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