Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1525)
DME Name Cytochrome P450 101D2 (cyp101), Novosphingobium aromaticivorans DME Info
UniProt ID
Q2G8A2_NOVAD
EC Number    EC: 1.14.15.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Iron-sulfur protein donor oxidoreductase
EC: 1.14.15.1
Lineage    Species: Novosphingobium aromaticivorans     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Alphaproteobacteria
Order: Sphingomonadales
Family: Sphingomonadaceae
Genus: Novosphingobium
Species: Novosphingobium aromaticivorans
Subspecies: Novosphingobium aromaticivorans DSM 12444
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: BRN-1907611 Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            Cytochrome P450 2A6 (CYP2A6) Click to Show/Hide the Cometabolization Info
DME ID DME0005 DME Info
Uniprot ID
CP2A6_HUMAN
Interaction Name CYP2A6-cyp101 interaction [1], [2], [3]
Description The interaction, between human Cytochrome P450 2A6 and Cytochrome P450 101D2 from Novosphingobium aromaticivorans which collectively metabolize the drug BRN-1907611, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Patients with primary biliary cirrhosis react against a ubiquitous xenobiotic-metabolizing bacterium. Hepatology. 2003 Nov;38(5):1250-7.
2 A cytochrome P450 class I electron transfer system from Novosphingobium aromaticivorans. Appl Microbiol Biotechnol. 2010 Mar;86(1):163-75.
3 In vitro metabolism of (-)-camphor using human liver microsomes and CYP2A6. Biol Pharm Bull. 2007 Feb;30(2):230-3.

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