Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1631)
DME Name VanA ligase (vanA), Enterococcus casseliflavus DME Info
UniProt ID
A0A4U9YK96_ENTCA
EC Number    EC: 6.3.2.4     (Click to Show/Hide the Complete EC Tree)
Ligase
Carbon-nitrogen ligase
Peptide synthase
EC: 6.3.2.4
Lineage    Species: Enterococcus casseliflavus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Enterococcaceae
Genus: Enterococcus
Species: Enterococcus casseliflavus
Subspecies: Enterococcus casseliflavus BM4232
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Teicoplanin Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            Sulfotransferase 1A1 (SULT1A1) Click to Show/Hide the Cometabolization Info
DME ID DME0008 DME Info
Uniprot ID
ST1A1_HUMAN
Interaction Name SULT1A1-vanA interaction [1], [2], [3]
Description The interaction, between human Sulfotransferase 1A1 and VanA ligase from Enterococcus casseliflavus which collectively metabolize the drug Teicoplanin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 vanA in Enterococcus faecium, Enterococcus faecalis, and Enterococcus casseliflavus detected in French cattle. Foodborne Pathog Dis. 2009 Nov;6(9):1107-11.
2 Emergence of high-level resistance to glycopeptides in Enterococcus gallinarum and Enterococcus casseliflavus. Antimicrob Agents Chemother. 1994 Jul;38(7):1675-7.
3 The 2.7 A resolution structure of the glycopeptide sulfotransferase Teg14. Acta Crystallogr D Biol Crystallogr. 2010 Dec;66(Pt 12):1278-86.

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