Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1631)
DME Name VanA ligase (vanA), Enterococcus casseliflavus
Synonyms Vancomycin/teicoplanin A-type resistance protein VanA; D-alanylalanine synthetase VanA; D-alanine--D-alanine ligase VanA; D-Ala-D-Ala ligase VanA; NCTC4725_01016; vanA
Gene Name vanA
UniProt ID
A0A4U9YK96_ENTCA
EC Number    EC: 6.3.2.4     (Click to Show/Hide the Complete EC Tree)
Ligase
Carbon-nitrogen ligase
Peptide synthase
EC: 6.3.2.4
Lineage    Species: Enterococcus casseliflavus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Enterococcaceae
Genus: Enterococcus
Species: Enterococcus casseliflavus
Subspecies: Enterococcus casseliflavus BM4232
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MKKIAIIFGGNSPEYTVSLASATSAIEALQSSPYDYDLSLIGIAPDAMDWYLYTGELENI
RQDTWLLDTKHTQKIQPLFEGNGFWISEAQQTLVPDVLFPIMHGKYGEDGSIQGLFELMK
LPYVGCGVAASALCMNKWLLHQAAAAIGVQSAPTILLTNQANQQRQIEAFIQTHGFPVFF
KPNEAGSSKGITKVTCVEEIAPALKEAFAYCSAVLLQKNIAGVEIGCGILGNDSLTVGAC
DAISLVDGFFDFEEKYQLISAKITVPAPLPETIETKVKEQAQLLYHSLGLKGLARIDFFV
TDQGELYLNEINTMPGFTSHSRYPAMMAAVGLSYQELLQKLLVLAKEEGK
Function This enzyme is involved with UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---L-lysine ligase (EC 6.3.2.7) or UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---2,6-diaminopimelate ligase (EC 6.3.2.13), UDP-N-acetylmuramate---L-alanine ligase (EC 6.3.2.8), UDP-N-acetylmuramoyl-L-alanine---D-glutamate ligase (EC 6.3.2.9) and UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase (EC 6.3.2.10) in the synthesis of a cell-wall peptide.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Vancomycin
 Drug Info Approved Methicillin-resistant staphylococcus infection ICD11: 1D01 [1], [2]
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Teicoplanin
 Drug Info Phase 4 Staphylococcus infection ICD11: 1B73 [1], [2]
References
1 vanA in Enterococcus faecium, Enterococcus faecalis, and Enterococcus casseliflavus detected in French cattle. Foodborne Pathog Dis. 2009 Nov;6(9):1107-11.
2 Emergence of high-level resistance to glycopeptides in Enterococcus gallinarum and Enterococcus casseliflavus. Antimicrob Agents Chemother. 1994 Jul;38(7):1675-7.

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