Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1864)
DME Name Flavin adenine dinucleotide dehydrogenase (fadd), Clostridium leptum DME Info
UniProt ID
APBE1_KLEP3
EC Number    EC: 1.5.1.37     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-NH donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.5.1.37
Lineage    Species: Clostridium leptum     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Ruminococcaceae
Genus: Clostridium
Species: Clostridium leptum
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: RO-7-0207 Click to Show/Hide the Full List of HOSPPI:        3 HOSPPI
                            Cytochrome P450 3A4 (CYP3A4) Click to Show/Hide the Cometabolization Info
DME ID DME0001 DME Info
Uniprot ID
CP3A4_HUMAN
Interaction Name CYP3A4-fadd interaction [1], [2]
Description The interaction, between human Cytochrome P450 3A4 and Flavin adenine dinucleotide dehydrogenase from Clostridium leptum which collectively metabolize the drug RO-7-0207, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A5 (CYP3A5) Click to Show/Hide the Cometabolization Info
DME ID DME0012 DME Info
Uniprot ID
CP3A5_HUMAN
Interaction Name CYP3A5-fadd interaction [1], [2]
Description The interaction, between human Cytochrome P450 3A5 and Flavin adenine dinucleotide dehydrogenase from Clostridium leptum which collectively metabolize the drug RO-7-0207, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A7 (CYP3A7) Click to Show/Hide the Cometabolization Info
DME ID DME0015 DME Info
Uniprot ID
CP3A7_HUMAN
Interaction Name CYP3A7-fadd interaction [1], [2]
Description The interaction, between human Cytochrome P450 3A7 and Flavin adenine dinucleotide dehydrogenase from Clostridium leptum which collectively metabolize the drug RO-7-0207, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Reduction of azo dyes and nitroaromatic compounds by bacterial enzymes from the human intestinal tract. Environ Health Perspect. 1995 Jun;103 Suppl 5:17-9.
2 Effect of ketoconazole on the pharmacokinetics of ornidazole--a possible role of p-glycoprotein and CYP3A. Drug Metabol Drug Interact. 2006;22(1):67-77.

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