Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1968)
DME Name Nitroreductase (NTR), Salmonella typhimurium DME Info
UniProt ID
A0A5K1UB29_SALTM
EC Number    EC: 1.5.1.39     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-NH donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.5.1.39
Lineage    Species: Salmonella typhimurium     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Salmonella
Species: Salmonella typhimurium
Subspecies: Salmonella typhimurium subsp. enterica serovar Typhimurium
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Riboflavin Click to Show/Hide the Full List of HOSPPI:        7 HOSPPI
                            Acid phosphatase-like protein 1 (ACP6) Click to Show/Hide the Cometabolization Info
DME ID DME0231 DME Info
Uniprot ID
PPA6_HUMAN
Interaction Name ACP6-NTR interaction [1], [2], [3]
Description The interaction, between human Acid phosphatase-like protein 1 and Nitroreductase from Salmonella typhimurium which collectively metabolize the drug Riboflavin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 1A1 (CYP1A1) Click to Show/Hide the Cometabolization Info
DME ID DME0006 DME Info
Uniprot ID
CP1A1_HUMAN
Interaction Name CYP1A1-NTR interaction [1], [2], [4]
Description The interaction, between human Cytochrome P450 1A1 and Nitroreductase from Salmonella typhimurium which collectively metabolize the drug Riboflavin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Eosinophil peroxidase (EPX) Click to Show/Hide the Cometabolization Info
DME ID DME0244 DME Info
Uniprot ID
PERE_HUMAN
Interaction Name EPX-NTR interaction [1], [2], [3]
Description The interaction, between human Eosinophil peroxidase and Nitroreductase from Salmonella typhimurium which collectively metabolize the drug Riboflavin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Prostatic acid phosphatase (ACP3) Click to Show/Hide the Cometabolization Info
DME ID DME0232 DME Info
Uniprot ID
PPAP_HUMAN
Interaction Name ACP3-NTR interaction [1], [2], [3]
Description The interaction, between human Prostatic acid phosphatase and Nitroreductase from Salmonella typhimurium which collectively metabolize the drug Riboflavin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Tartrate-resistant acid ATPase (ACP5) Click to Show/Hide the Cometabolization Info
DME ID DME0230 DME Info
Uniprot ID
PPA5_HUMAN
Interaction Name ACP5-NTR interaction [1], [2], [3]
Description The interaction, between human Tartrate-resistant acid ATPase and Nitroreductase from Salmonella typhimurium which collectively metabolize the drug Riboflavin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Testicular acid phosphatase (ACP4) Click to Show/Hide the Cometabolization Info
DME ID DME0229 DME Info
Uniprot ID
PPAT_HUMAN
Interaction Name ACP4-NTR interaction [1], [2], [3]
Description The interaction, between human Testicular acid phosphatase and Nitroreductase from Salmonella typhimurium which collectively metabolize the drug Riboflavin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Xylosyl phosphatase (PXYLP1) Click to Show/Hide the Cometabolization Info
DME ID DME0250 DME Info
Uniprot ID
PXYP1_HUMAN
Interaction Name PXYLP1-NTR interaction [1], [2], [3]
Description The interaction, between human Xylosyl phosphatase and Nitroreductase from Salmonella typhimurium which collectively metabolize the drug Riboflavin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
               Cometabolized drug: Niclosamide Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            Cytochrome P450 2C9 (CYP2C9) Click to Show/Hide the Cometabolization Info
DME ID DME0019 DME Info
Uniprot ID
CP2C9_HUMAN
Interaction Name CYP2C9-NTR interaction [5], [6]
Description The interaction, between human Cytochrome P450 2C9 and Nitroreductase from Salmonella typhimurium which collectively metabolize the drug Niclosamide, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
               Cometabolized drug: Nitrazepam Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            Cytochrome P450 3A4 (CYP3A4) Click to Show/Hide the Cometabolization Info
DME ID DME0001 DME Info
Uniprot ID
CP3A4_HUMAN
Interaction Name CYP3A4-NTR interaction [1], [2], [7]
Description The interaction, between human Cytochrome P450 3A4 and Nitroreductase from Salmonella typhimurium which collectively metabolize the drug Nitrazepam, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
               Cometabolized drug: Mononitrophenol Click to Show/Hide the Full List of HOSPPI:        2 HOSPPI
                            Sulfotransferase 1A2 (SULT1A2) Click to Show/Hide the Cometabolization Info
DME ID DME0062 DME Info
Uniprot ID
ST1A2_HUMAN
Interaction Name SULT1A2-NTR interaction [1], [2], [8]
Description The interaction, between human Sulfotransferase 1A2 and Nitroreductase from Salmonella typhimurium which collectively metabolize the drug Mononitrophenol, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Sulfotransferase 1B1 (SULT1B1) Click to Show/Hide the Cometabolization Info
DME ID DME0380 DME Info
Uniprot ID
ST1B1_HUMAN
Interaction Name SULT1B1-NTR interaction [1], [2], [9]
Description The interaction, between human Sulfotransferase 1B1 and Nitroreductase from Salmonella typhimurium which collectively metabolize the drug Mononitrophenol, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Purification and characterization of wild-type and mutant "classical" nitroreductases of Salmonella typhimurium. L33R mutation greatly diminishes binding of FMN to the nitroreductase of S. typhimurium. J Biol Chem. 1998 Sep 11;273(37):23922-8.
2 Prenatal diagnosis of junctional epidermolysis bullosa Herlitz type. Lancet. 1989 Oct 28;2(8670):1035-6. Letter
3 An atlas of human metabolism. Sci Signal. 2020 Mar 24;13(624). pii: eaaz1482. (Reaction HMR_6507)
4 Disruption of endogenous regulator homeostasis underlies the mechanism of rat CYP1A1 mRNA induction by metyrapone. Biochem J. 1998 Apr 1;331 ( Pt 1):273-81.
5 CYP1A1 and Cnr nitroreductase bioactivated niclosamide in vitro. Mutagenesis. 2013 Nov;28(6):645-51.
6 Generation and evaluation of a CYP2C9 heteroactivation pharmacophore. J Pharmacol Exp Ther. 2003 Dec;307(3):878-87.
7 Prediction of metabolic clearance using fresh human hepatocytes: comparison with cryopreserved hepatocytes and hepatic microsomes for five benzodiazepines. Xenobiotica. 2008 Apr;38(4):353-67.
8 cDNA cloning and expression of a new form of human aryl sulfotransferase. Int J Biochem Cell Biol. 1996 May;28(5):565-71.
9 Comparison of 2-aminophenol and 4-nitrophenol as in vitro probe substrates for the major human hepatic sulfotransferase, SULT1A1, demonstrates improved selectivity with 2-aminophenol. Biochem Pharmacol. 2007 Jul 15;74(2):352-8.

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