Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1971)
DME Name Oxygen-insensitive NADPH nitroreductase A (nfsA), Salmonella enterica DME Info
UniProt ID
NFSA_SALTY
EC Number    EC: 1.5.1.38     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-NH donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.5.1.38
Lineage    Species: Salmonella enterica     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Salmonella
Species: Salmonella enterica
Subspecies: Salmonella enterica subsp. enterica serovar Typhimurium
Subspecies: Salmonella enterica subsp. enterica serovar Typhimurium TA100
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Nitrazepam Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            Cytochrome P450 3A4 (CYP3A4) Click to Show/Hide the Cometabolization Info
DME ID DME0001 DME Info
Uniprot ID
CP3A4_HUMAN
Interaction Name CYP3A4-nfsA interaction [1], [2]
Description The interaction, between human Cytochrome P450 3A4 and Oxygen-insensitive NADPH nitroreductase A from Salmonella enterica which collectively metabolize the drug Nitrazepam, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
               Cometabolized drug: RO-7-0207 Click to Show/Hide the Full List of HOSPPI:        3 HOSPPI
                            Cytochrome P450 3A4 (CYP3A4) Click to Show/Hide the Cometabolization Info
DME ID DME0001 DME Info
Uniprot ID
CP3A4_HUMAN
Interaction Name CYP3A4-nfsA interaction [1], [3]
Description The interaction, between human Cytochrome P450 3A4 and Oxygen-insensitive NADPH nitroreductase A from Salmonella enterica which collectively metabolize the drug RO-7-0207, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A5 (CYP3A5) Click to Show/Hide the Cometabolization Info
DME ID DME0012 DME Info
Uniprot ID
CP3A5_HUMAN
Interaction Name CYP3A5-nfsA interaction [1], [3]
Description The interaction, between human Cytochrome P450 3A5 and Oxygen-insensitive NADPH nitroreductase A from Salmonella enterica which collectively metabolize the drug RO-7-0207, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A7 (CYP3A7) Click to Show/Hide the Cometabolization Info
DME ID DME0015 DME Info
Uniprot ID
CP3A7_HUMAN
Interaction Name CYP3A7-nfsA interaction [1], [3]
Description The interaction, between human Cytochrome P450 3A7 and Oxygen-insensitive NADPH nitroreductase A from Salmonella enterica which collectively metabolize the drug RO-7-0207, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Identification and characterization of SnrA, an inducible oxygen-insensitive nitroreductase in Salmonella enterica serovar Typhimurium TA1535. Mutat Res. 2002 Oct 31;508(1-2):59-70.
2 Prediction of metabolic clearance using fresh human hepatocytes: comparison with cryopreserved hepatocytes and hepatic microsomes for five benzodiazepines. Xenobiotica. 2008 Apr;38(4):353-67.
3 Effect of ketoconazole on the pharmacokinetics of ornidazole--a possible role of p-glycoprotein and CYP3A. Drug Metabol Drug Interact. 2006;22(1):67-77.

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