Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME2100)
DME Name Beta-lactamase (blaB), Burkholderia multivorans DME Info
UniProt ID
PENA_BURM1
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Burkholderia multivorans     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Betaproteobacteria
Order: Burkholderiales
Family: Burkholderiaceae
Genus: Burkholderia
Species: Burkholderia multivorans
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Cefaloridine Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            Cytochrome P450 2C8 (CYP2C8) Click to Show/Hide the Cometabolization Info
DME ID DME0018 DME Info
Uniprot ID
CP2C8_HUMAN
Interaction Name CYP2C8-blaB interaction [1], [2]
Description The interaction, between human Cytochrome P450 2C8 and Beta-lactamase from Burkholderia multivorans which collectively metabolize the drug Cefaloridine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Characterization of the penA and penR genes of Burkholderia cepacia 249 which encode the chromosomal class A penicillinase and its LysR-type transcriptional regulator. Antimicrob Agents Chemother. 1997 Nov;41(11):2399-405.
2 Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: analysis of the mechanism of the clinically relevant drug-drug interaction between cerivastatin and gemfibrozil. J Pharmacol Exp Ther. 2004 Oct;311(1):228-36.

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