Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0013)
DME Name Cytochrome P450 2E1 (CYP2E1), Homo sapiens DME Info
UniProt ID
CP2E1_HUMAN
EC Number    EC: 1.14.14.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Flavin/flavoprotein donor oxidoreductase
EC: 1.14.14.1
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Actinobacteria
                  Bifidobacterium adolescentis (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Bifidobacterium adolescentis co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bifidobacterium breve (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Bifidobacterium breve co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bifidobacterium longum (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Bifidobacterium longum co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bifidobacterium ruminatum (actinobacteria) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Bupropion Click to Show/Hide the Detail
                                 Drug ID DR0247   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Bifidobacterium ruminatum co-metabolize the drug Bupropion, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Bifidobacterium ruminatum co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Fluvoxamine maleate Click to Show/Hide the Detail
                                 Drug ID DR0740   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Bifidobacterium ruminatum co-metabolize the drug Fluvoxamine maleate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Eggerthella lenta (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Eszopiclone Click to Show/Hide the Detail
                                 Drug ID DR0652   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Eggerthella lenta co-metabolize the drug Eszopiclone, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                  Nocardia farcinica (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Rifampicin Click to Show/Hide the Detail
                                 Drug ID DR1420   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Nocardia farcinica co-metabolize the drug Rifampicin, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [6]
                  Tsukamurella paurometabola (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Isoniazid Click to Show/Hide the Detail
                                 Drug ID DR0886   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Tsukamurella paurometabola co-metabolize the drug Isoniazid, which can collectively affect efficacy, safety or bioavailability of this drug. [7], [8], [9]
      Bacteria: Bacteroidetes
                  Alistipes indistinctus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Alistipes indistinctus co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides coprophilus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Bacteroides coprophilus co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [10], [2]
                              Eszopiclone Click to Show/Hide the Detail
                                 Drug ID DR0652   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Bacteroides coprophilus co-metabolize the drug Eszopiclone, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                  Bacteroides dorei (CFB bacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Bacteroides dorei co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [10], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Bacteroides dorei co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides eggerthii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Bacteroides eggerthii co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides fragilis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Bacteroides fragilis co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [10], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Bacteroides fragilis co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides intestinalis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Bacteroides intestinalis co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides ovatus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Bacteroides ovatus co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [10], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Bacteroides ovatus co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides sartorii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Bacteroides sartorii co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [10], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Bacteroides sartorii co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides stercoris (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Bacteroides stercoris co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides thetaiotaomicron (CFB bacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Bacteroides thetaiotaomicron co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [10], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Bacteroides thetaiotaomicron co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides uniformis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Bacteroides uniformis co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides vulgatus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Bacteroides vulgatus co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Verapamil hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1681   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Bacteroides vulgatus co-metabolize the drug Verapamil hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [2]
                  Bacteroides xylanisolvens (CFB bacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Bacteroides xylanisolvens co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [10], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Bacteroides xylanisolvens co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Odoribacter splanchnicus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Odoribacter splanchnicus co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Parabacteroides distasonis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Parabacteroides distasonis co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Parabacteroides johnsonii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Parabacteroides johnsonii co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Parabacteroides merdae (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Parabacteroides merdae co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Prevotella copri (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Prevotella copri co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Chlamydiae
                  Chlamydia muridarum (chlamydias) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Folic acid Click to Show/Hide the Detail
                                 Drug ID DR0742   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Chlamydia muridarum co-metabolize the drug Folic acid, which can collectively affect efficacy, safety or bioavailability of this drug. [12], [13], [14]
      Bacteria: Cyanobacteria
                  Synechococcus elongatus (cyanobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Isoniazid Click to Show/Hide the Detail
                                 Drug ID DR0886   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Synechococcus elongatus co-metabolize the drug Isoniazid, which can collectively affect efficacy, safety or bioavailability of this drug. [7], [15]
      Bacteria: Firmicutes
                  Anaerobutyricum hallii (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Eszopiclone Click to Show/Hide the Detail
                                 Drug ID DR0652   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Anaerobutyricum hallii co-metabolize the drug Eszopiclone, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Anaerobutyricum hallii co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Anaerococcus hydrogenalis (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Eszopiclone Click to Show/Hide the Detail
                                 Drug ID DR0652   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Anaerococcus hydrogenalis co-metabolize the drug Eszopiclone, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                  Bacillus megaterium (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Acetaminophen Click to Show/Hide the Detail
                                 Drug ID DR0037   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Bacillus megaterium co-metabolize the drug Acetaminophen, which can collectively affect efficacy, safety or bioavailability of this drug. [16], [17]
                              Chlorzoxazone Click to Show/Hide the Detail
                                 Drug ID DR0312   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Bacillus megaterium co-metabolize the drug Chlorzoxazone, which can collectively affect efficacy, safety or bioavailability of this drug. [18], [19], [17]
                  Bacteroides pectinophilus (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Bacteroides pectinophilus co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Blautia hansenii (firmicutes) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Blautia hansenii co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [10], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Blautia hansenii co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Fluvoxamine maleate Click to Show/Hide the Detail
                                 Drug ID DR0740   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Blautia hansenii co-metabolize the drug Fluvoxamine maleate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Sildenafil citrate Click to Show/Hide the Detail
                                 Drug ID DR1481   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Blautia hansenii co-metabolize the drug Sildenafil citrate, which can collectively affect efficacy, safety or bioavailability of this drug. [20], [2]
                  Clostridioides difficile (firmicutes) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Acetaminophen Click to Show/Hide the Detail
                                 Drug ID DR0037   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Clostridioides difficile co-metabolize the drug Acetaminophen, which can collectively affect efficacy, safety or bioavailability of this drug. [16], [21]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Clostridioides difficile co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Sildenafil citrate Click to Show/Hide the Detail
                                 Drug ID DR1481   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Clostridioides difficile co-metabolize the drug Sildenafil citrate, which can collectively affect efficacy, safety or bioavailability of this drug. [20], [2]
                  Clostridium botulinum (firmicutes) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Eszopiclone Click to Show/Hide the Detail
                                 Drug ID DR0652   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Clostridium botulinum co-metabolize the drug Eszopiclone, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Clostridium botulinum co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Fluvoxamine maleate Click to Show/Hide the Detail
                                 Drug ID DR0740   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Clostridium botulinum co-metabolize the drug Fluvoxamine maleate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Sildenafil citrate Click to Show/Hide the Detail
                                 Drug ID DR1481   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Clostridium botulinum co-metabolize the drug Sildenafil citrate, which can collectively affect efficacy, safety or bioavailability of this drug. [20], [2]
                  Clostridium sporogenes (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Clostridium sporogenes co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [10], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Clostridium sporogenes co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Clostridium symbiosum (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Eszopiclone Click to Show/Hide the Detail
                                 Drug ID DR0652   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Clostridium symbiosum co-metabolize the drug Eszopiclone, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                  Dorea formicigenerans (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Dorea formicigenerans co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Enterocloster asparagiformis (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Enterocloster asparagiformis co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Enterocloster bolteae (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Enterocloster bolteae co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Enterococcus faecalis (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Acetaminophen Click to Show/Hide the Detail
                                 Drug ID DR0037   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Enterococcus faecalis co-metabolize the drug Acetaminophen, which can collectively affect efficacy, safety or bioavailability of this drug. [16], [21]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Enterococcus faecalis co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Erysipelatoclostridium ramosum (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Erysipelatoclostridium ramosum co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Eubacterium rectale (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Eszopiclone Click to Show/Hide the Detail
                                 Drug ID DR0652   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Eubacterium rectale co-metabolize the drug Eszopiclone, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Eubacterium rectale co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Eubacterium ventriosum (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Eubacterium ventriosum co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Faecalibacterium prausnitzii (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Menadione Click to Show/Hide the Detail
                                 Drug ID DR1022   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Faecalibacterium prausnitzii co-metabolize the drug Menadione, which can collectively affect efficacy, safety or bioavailability of this drug. [22], [23]
                  Holdemanella biformis (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Holdemanella biformis co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [10], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Holdemanella biformis co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Lactobacillus casei (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Folic acid Click to Show/Hide the Detail
                                 Drug ID DR0742   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Lactobacillus casei co-metabolize the drug Folic acid, which can collectively affect efficacy, safety or bioavailability of this drug. [12], [24], [25]
                  Lactobacillus johnsonii (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Tegafur Click to Show/Hide the Detail
                                 Drug ID DR1539   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Lactobacillus johnsonii co-metabolize the drug Tegafur, which can collectively affect efficacy, safety or bioavailability of this drug. [26], [27]
                  Lactobacillus reuteri (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Lactobacillus reuteri co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Marvinbryantia formatexigens (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Eszopiclone Click to Show/Hide the Detail
                                 Drug ID DR0652   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Marvinbryantia formatexigens co-metabolize the drug Eszopiclone, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                  Roseburia intestinalis (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Roseburia intestinalis co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [10], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Roseburia intestinalis co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Ruminococcus gnavus (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Ruminococcus gnavus co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Ruminococcus lactaris (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Eszopiclone Click to Show/Hide the Detail
                                 Drug ID DR0652   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Ruminococcus lactaris co-metabolize the drug Eszopiclone, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Ruminococcus lactaris co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Subdoligranulum variabile (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Subdoligranulum variabile co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Proteobacteria
                  Citrobacter freundii (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Acetaminophen Click to Show/Hide the Detail
                                 Drug ID DR0037   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Citrobacter freundii co-metabolize the drug Acetaminophen, which can collectively affect efficacy, safety or bioavailability of this drug. [16], [21]
                  Enterobacter cancerogenus (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Enterobacter cancerogenus co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Escherichia coli (enterobacteria) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Acetaminophen Click to Show/Hide the Detail
                                 Drug ID DR0037   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Escherichia coli co-metabolize the drug Acetaminophen, which can collectively affect efficacy, safety or bioavailability of this drug. [16], [21]
                              Bupropion Click to Show/Hide the Detail
                                 Drug ID DR0247   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Escherichia coli co-metabolize the drug Bupropion, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Escherichia coli co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Folic acid Click to Show/Hide the Detail
                                 Drug ID DR0742   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Escherichia coli co-metabolize the drug Folic acid, which can collectively affect efficacy, safety or bioavailability of this drug. [12], [28], [29]
                  Neisseria sicca (beta-proteobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Ethanol Click to Show/Hide the Detail
                                 Drug ID DR0655   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Neisseria sicca co-metabolize the drug Ethanol, which can collectively affect efficacy, safety or bioavailability of this drug. [30], [31]
                  Proteus penneri (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Proteus penneri co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Providencia stuartii (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Providencia stuartii co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Pseudomonas putida (gamma-proteobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Nicotine Click to Show/Hide the Detail
                                 Drug ID DR1148   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Pseudomonas putida co-metabolize the drug Nicotine, which can collectively affect efficacy, safety or bioavailability of this drug. [32], [33]
                  Salmonella enterica (enterobacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Salmonella enterica co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Menadione Click to Show/Hide the Detail
                                 Drug ID DR1022   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Salmonella enterica co-metabolize the drug Menadione, which can collectively affect efficacy, safety or bioavailability of this drug. [22], [34], [35]
      Fungi: Ascomycota
                  Saccharomyces cerevisiae (ascomycota) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Acetaminophen Click to Show/Hide the Detail
                                 Drug ID DR0037   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) metabolizes the drug Acetaminophen, and Saccharomyces cerevisiae further metabolizes its metabolite (1-Phenyl-1,2-propanedione), which can indirectly affect efficacy, safety or bioavailability of this drug. [16], [21]
      Archaea: Euryarchaeota
                  Methanobrevibacter oralis (methanobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Rifampicin Click to Show/Hide the Detail
                                 Drug ID DR1420   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Methanobrevibacter oralis co-metabolize the drug Rifampicin, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [36]
                  Methanobrevibacter smithii (methanobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Rifampicin Click to Show/Hide the Detail
                                 Drug ID DR1420   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Methanobrevibacter smithii co-metabolize the drug Rifampicin, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [36]
                  Methanomassiliicoccus luminyensis (thermoplasmata) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Rifampicin Click to Show/Hide the Detail
                                 Drug ID DR1420   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Methanomassiliicoccus luminyensis co-metabolize the drug Rifampicin, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [36]
                  Methanosphaera stadtmanae (methanobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Rifampicin Click to Show/Hide the Detail
                                 Drug ID DR1420   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2E1 (CYP2E1) and Methanosphaera stadtmanae co-metabolize the drug Rifampicin, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [36]
References
1 Antidepressant drugs in the elderly--role of the cytochrome P450 2D6. World J Biol Psychiatry. 2003 Apr;4(2):74-80.
2 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.
3 Validation of bupropion hydroxylation as a selective marker of human cytochrome P450 2B6 catalytic activity. Drug Metab Dispos. 2000 Oct;28(10):1222-30.
4 Eszopiclone, a nonbenzodiazepine sedative-hypnotic agent for the treatment of transient and chronic insomnia. Clin Ther. 2006 Apr;28(4):491-516.
5 Protective effect of rifampicin against acute liver injury induced by carbon tetrachloride in mice. Jpn J Pharmacol. 1995 Dec;69(4):325-34.
6 Mechanism of rifampicin inactivation in Nocardia farcinica. PLoS One. 2016 Oct 5;11(10):e0162578.
7 Inhibition of CYP2E1 catalytic activity in vitro by S-adenosyl-L-methionine. Biochem Pharmacol. 2005 Apr 1;69(7):1081-93.
8 The actinobacterium Tsukamurella paurometabola has a functionally divergent arylamine N-acetyltransferase (NAT) homolog. World J Microbiol Biotechnol. 2019 Oct 31;35(11):174.
9 Complete genome sequence of Tsukamurella paurometabola type strain (no. 33). Stand Genomic Sci. 2011 Jul 1;4(3):342-51.
10 In vitro identification of the human cytochrome P450 enzymes involved in the metabolism of R(+)- and S(-)-carvedilol. Drug Metab Dispos. 1997 Aug;25(8):970-7.
11 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
12 Chronic ethanol feeding and folate deficiency activate hepatic endoplasmic reticulum stress pathway in micropigs. Am J Physiol Gastrointest Liver Physiol. 2005 Jul;289(1):G54-63.
13 Biophysical principles predict fitness landscapes of drug resistance. Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):E1470-8.
14 The Genital tract virulence factor pGP3 is essential for Chlamydia muridarum colonization in the gastrointestinal tract. Infect Immun. 2017 Dec 19;86(1). pii: e00429-17.
15 Crystal structure of the catalase-peroxidase KatG W78F mutant from Synechococcus elongatus PCC7942 in complex with the antitubercular pro-drug isoniazid. FEBS Lett. 2015 Jan 2;589(1):131-7.
16 Acetaminophen induced acute liver failure via oxidative stress and JNK activation: protective role of taurine by the suppression of cytochrome P450 2E1. Free Radic Res. 2010 Mar;44(3):340-55.
17 The bacterial P450 BM3: a prototype for a biocatalyst with human P450 activities. Trends Biotechnol. 2007 Jul;25(7):289-98.
18 Trimethadione metabolism by human liver cytochrome P450: evidence for the involvement of CYP2E1. Xenobiotica. 1998 Nov;28(11):1041-7.
19 Wild-type CYP102A1 as a biocatalyst: turnover of drugs usually metabolised by human liver enzymes. J Biol Inorg Chem. 2007 Mar;12(3):313-23.
20 Erectile dysfunction drugs changed the protein expressions and activities of drug-metabolising enzymes in the liver of male rats. Oxid Med Cell Longev. 2016;2016:4970906.
21 Gut microbiota mediates diurnal variation of acetaminophen induced acute liver injury in mice. J Hepatol. 2018 Jul;69(1):51-59.
22 CYP2E1 overexpression alters hepatocyte death from menadione and fatty acids by activation of ERK1/2 signaling. Hepatology. 2004 Feb;39(2):444-55.
23 Quinones are growth factors for the human gut microbiota. Microbiome. 2017 Dec 20;5(1):161.
24 Molecular cloning of the gene for dihydrofolate reductase from Lactobacillus casei. Gene. 1982 Feb;17(2):229-33.
25 Mutagenesis of folylpolyglutamate synthetase indicates that dihydropteroate and tetrahydrofolate bind to the same site. Biochemistry. 2008 Feb 26;47(8):2388-96.
26 Roles of cytochromes P450 1A2, 2A6, and 2C8 in 5-fluorouracil formation from tegafur, an anticancer prodrug, in human liver microsomes. Drug Metab Dispos. 2000 Dec;28(12):1457-63.
27 Activation of multiple chemotherapeutic prodrugs by the natural enzymolome of tumour-localised probiotic bacteria. J Control Release. 2016 Jan 28;222:9-17.
28 Measurement of the uptake of radioactive para-aminobenzoic acid monitors folate biosynthesis in Escherichia coli K-12. Anal Biochem. 1994 Feb 1;216(2):427-30.
29 The influence of CsgD on the expression of genes of folate metabolism and hmp in Escherichia coli K-12. Arch Microbiol. 2013 Aug;195(8):559-69.
30 CYP2E1 and clinical features in alcoholics. Neuropsychobiology. 2003;47(2):86-9.
31 Functional profiles of coronal and dentin caries in children. J Oral Microbiol. 2018 Jul 16;10(1):1495976.
32 Effects of nicotine on cytochrome P450 2A6 and 2E1 activities. Br J Clin Pharmacol. 2010 Feb;69(2):152-9.
33 Optimization of a nicotine degrading enzyme for potential use in treatment of nicotine addiction. BMC Biotechnol. 2019 Aug 2;19(1):56.
34 Purification and characterization of wild-type and mutant "classical" nitroreductases of Salmonella typhimurium. L33R mutation greatly diminishes binding of FMN to the nitroreductase of S. typhimurium. J Biol Chem. 1998 Sep 11;273(37):23922-8.
35 Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol. 2001 Jun;183(11):3417-27.
36 The antimicrobial resistance pattern of cultured human methanogens reflects the unique phylogenetic position of archaea. J Antimicrob Chemother. 2011 Sep;66(9):2038-44.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.