Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0026)
DME Name Vitamin D(3) 25-hydroxylase (CYP27A1), Homo sapiens DME Info
UniProt ID
CP27A_HUMAN
EC Number    EC: 1.14.15.15     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Iron-sulfur protein donor oxidoreductase
EC: 1.14.15.15
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Actinobacteria
                  Mycobacterium tuberculosis (actinobacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              ANW-32821 Click to Show/Hide the Detail
                                 Drug ID DR2314   Drug Info
                                 Interaction Mechanism Human Vitamin D(3) 25-hydroxylase (CYP27A1) and Mycobacterium tuberculosis co-metabolize the drug ANW-32821, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Vitamin D Click to Show/Hide the Detail
                                 Drug ID DR1700   Drug Info
                                 Interaction Mechanism Human Vitamin D(3) 25-hydroxylase (CYP27A1) and Mycobacterium tuberculosis co-metabolize the drug Vitamin D, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [4]
                  Mycolicibacterium smegmatis (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              ANW-32821 Click to Show/Hide the Detail
                                 Drug ID DR2314   Drug Info
                                 Interaction Mechanism Human Vitamin D(3) 25-hydroxylase (CYP27A1) and Mycolicibacterium smegmatis co-metabolize the drug ANW-32821, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [5]
      Bacteria: Firmicutes
                  Eubacterium coprostanoligenes (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              ANW-32821 Click to Show/Hide the Detail
                                 Drug ID DR2314   Drug Info
                                 Interaction Mechanism Human Vitamin D(3) 25-hydroxylase (CYP27A1) and Eubacterium coprostanoligenes co-metabolize the drug ANW-32821, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [6]
References
1 Cholesterol-metabolizing cytochromes P450. Drug Metab Dispos. 2006 Apr;34(4):513-20.
2 Function, essentiality, and expression of cytochrome P450 enzymes and their cognate redox partners in Mycobacterium tuberculosis: are they drug targets? Appl Microbiol Biotechnol. 2019 May;103(9):3597-3614.
3 Chemoprevention of prostate cancer by cholecalciferol (vitamin D3): 25-hydroxylase (CYP27A1) in human prostate epithelial cells. Clin Exp Metastasis. 2005;22(3):265-73.
4 Identification of Mycobacterium tuberculosis enzyme involved in vitamin D and 7-dehydrocholesterol metabolism. J Steroid Biochem Mol Biol. 2017 May;169:202-209.
5 Cholesterol ester oxidation by mycobacterial cytochrome P450. J Biol Chem. 2014 Oct 31;289(44):30417-25.
6 Mechanism of cholesterol reduction to coprostanol by Eubacterium coprostanoligenes ATCC 51222. Steroids. 1996 Jan;61(1):33-40.

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