Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0028)
DME Name Cholesterol 24-hydroxylase (CYP46A1), Homo sapiens DME Info
UniProt ID
CP46A_HUMAN
EC Number    EC: 1.14.14.25     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Flavin/flavoprotein donor oxidoreductase
EC: 1.14.14.25
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Actinobacteria
                  Mycobacterium tuberculosis (actinobacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              ANW-32821 Click to Show/Hide the Detail
                                 Drug ID DR2314   Drug Info
                                 Interaction Mechanism Human Cholesterol 24-hydroxylase (CYP46A1) and Mycobacterium tuberculosis co-metabolize the drug ANW-32821, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Dextromethorphan hydrobromide Click to Show/Hide the Detail
                                 Drug ID DR0476   Drug Info
                                 Interaction Mechanism Human Cholesterol 24-hydroxylase (CYP46A1) and Mycobacterium tuberculosis co-metabolize the drug Dextromethorphan hydrobromide, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Mycolicibacterium smegmatis (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              ANW-32821 Click to Show/Hide the Detail
                                 Drug ID DR2314   Drug Info
                                 Interaction Mechanism Human Cholesterol 24-hydroxylase (CYP46A1) and Mycolicibacterium smegmatis co-metabolize the drug ANW-32821, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [4]
                  Streptomyces avermitilis (actinobacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human Cholesterol 24-hydroxylase (CYP46A1) and Streptomyces avermitilis co-metabolize the drug Diclofenac sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [5], [6]
                              Testosterone cypionate Click to Show/Hide the Detail
                                 Drug ID DR1564   Drug Info
                                 Interaction Mechanism Human Cholesterol 24-hydroxylase (CYP46A1) and Streptomyces avermitilis co-metabolize the drug Testosterone cypionate, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [7], [5]
      Bacteria: Bacteroidetes
                  Bacteroides dorei (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human Cholesterol 24-hydroxylase (CYP46A1) metabolizes the drug Diclofenac sodium, and Bacteroides dorei further metabolizes its metabolite (Diclofenac glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug. [3], [8]
      Bacteria: Firmicutes
                  Bacillus megaterium (firmicutes) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Dextromethorphan hydrobromide Click to Show/Hide the Detail
                                 Drug ID DR0476   Drug Info
                                 Interaction Mechanism Human Cholesterol 24-hydroxylase (CYP46A1) and Bacillus megaterium co-metabolize the drug Dextromethorphan hydrobromide, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [9]
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human Cholesterol 24-hydroxylase (CYP46A1) and Bacillus megaterium co-metabolize the drug Diclofenac sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [10]
                              Progesterone Click to Show/Hide the Detail
                                 Drug ID DR1346   Drug Info
                                 Interaction Mechanism Human Cholesterol 24-hydroxylase (CYP46A1) and Bacillus megaterium co-metabolize the drug Progesterone, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [11]
                              Testosterone cypionate Click to Show/Hide the Detail
                                 Drug ID DR1564   Drug Info
                                 Interaction Mechanism Human Cholesterol 24-hydroxylase (CYP46A1) and Bacillus megaterium co-metabolize the drug Testosterone cypionate, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [11], [12]
                  Eubacterium coprostanoligenes (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              ANW-32821 Click to Show/Hide the Detail
                                 Drug ID DR2314   Drug Info
                                 Interaction Mechanism Human Cholesterol 24-hydroxylase (CYP46A1) and Eubacterium coprostanoligenes co-metabolize the drug ANW-32821, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [13]
                  Faecalibacterium prausnitzii (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human Cholesterol 24-hydroxylase (CYP46A1) metabolizes the drug Diclofenac sodium, and Faecalibacterium prausnitzii further metabolizes its metabolite (Diclofenac glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug. [3], [8]
                  Lactobacillus rhamnosus (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human Cholesterol 24-hydroxylase (CYP46A1) metabolizes the drug Diclofenac sodium, and Lactobacillus rhamnosus further metabolizes its metabolite (Diclofenac glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug. [3], [8]
                  Ruminococcus gnavus (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human Cholesterol 24-hydroxylase (CYP46A1) metabolizes the drug Diclofenac sodium, and Ruminococcus gnavus further metabolizes its metabolite (Diclofenac glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug. [3], [8]
References
1 Cholesterol-metabolizing cytochromes P450. Drug Metab Dispos. 2006 Apr;34(4):513-20.
2 Function, essentiality, and expression of cytochrome P450 enzymes and their cognate redox partners in Mycobacterium tuberculosis: are they drug targets? Appl Microbiol Biotechnol. 2019 May;103(9):3597-3614.
3 Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain. Biochemistry. 2003 Dec 9;42(48):14284-92.
4 Cholesterol ester oxidation by mycobacterial cytochrome P450. J Biol Chem. 2014 Oct 31;289(44):30417-25.
5 The metagenome of Caracolus marginella gut microbiome using culture independent approaches and shotgun sequencing. Data Brief. 2017 Nov 22;16:501-505.
6 Hydroxylation of Compactin (ML-236B) by CYP105D7 (SAV_7469) from Streptomyces avermitilis. J Microbiol Biotechnol. 2017 May 28;27(5):956-964.
7 Regio- and stereoselective hydroxylation of testosterone by a novel cytochrome P450 154C2 from Streptomyces avermitilis. Biochem Biophys Res Commun. 2020 Feb 5;522(2):355-361.
8 tructure, function, and inhibition of drug reactivating human gut microbial beta-glucuronidases. Sci Rep. 2019 Jan 29;9(1):825.
9 The bacterial P450 BM3: a prototype for a biocatalyst with human P450 activities. Trends Biotechnol. 2007 Jul;25(7):289-98.
10 Both reactivity and accessibility are important in cytochrome P450 metabolism: a combined DFT and MD study of fenamic acids in BM3 mutants. J Chem Inf Model. 2019 Feb 25;59(2):743-753.
11 acillus megaterium SF185 spores exert protective effects against oxidative stress in vivo and in vitro. Sci Rep. 2019 Aug 19;9(1):12082.
12 A Novel NADPH-dependent flavoprotein reductase from Bacillus megaterium acts as an efficient cytochrome P450 reductase. J Biotechnol. 2016 Aug 10;231:83-94.
13 Mechanism of cholesterol reduction to coprostanol by Eubacterium coprostanoligenes ATCC 51222. Steroids. 1996 Jan;61(1):33-40.

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