Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0037)
DME Name Steroid 21-hydroxylase (CYP21A2), Homo sapiens DME Info
UniProt ID
CP21A_HUMAN
EC Number    EC: 1.14.14.16     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Flavin/flavoprotein donor oxidoreductase
EC: 1.14.14.16
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Firmicutes
                  Bacillus megaterium (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Progesterone Click to Show/Hide the Detail
                                 Drug ID DR1346   Drug Info
                                 Interaction Mechanism Human Steroid 21-hydroxylase (CYP21A2) and Bacillus megaterium co-metabolize the drug Progesterone, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
References
1 Human cytochrome P450 21A2, the major steroid 21-hydroxylase: structure of the enzyme progesterone substrate complex and rate-limiting C-H bond cleavage. J Biol Chem. 2015 May 22;290(21):13128-43.
2 acillus megaterium SF185 spores exert protective effects against oxidative stress in vivo and in vitro. Sci Rep. 2019 Aug 19;9(1):12082.

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