Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0052)
DME Name Aldehyde oxidase (AOX1), Homo sapiens DME Info
UniProt ID
AOXA_HUMAN
EC Number    EC: 1.2.3.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Aldehyde/oxo donor oxidoreductase
Oxygen acceptor oxidoreductase
EC: 1.2.3.1
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Bacteroidetes
                  Bacteroides dorei (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Zaleplon Click to Show/Hide the Detail
                                 Drug ID DR1725   Drug Info
                                 Interaction Mechanism Human Aldehyde oxidase (AOX1) and Bacteroides dorei co-metabolize the drug Zaleplon, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides fragilis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Zaleplon Click to Show/Hide the Detail
                                 Drug ID DR1725   Drug Info
                                 Interaction Mechanism Human Aldehyde oxidase (AOX1) and Bacteroides fragilis co-metabolize the drug Zaleplon, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides sartorii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Zaleplon Click to Show/Hide the Detail
                                 Drug ID DR1725   Drug Info
                                 Interaction Mechanism Human Aldehyde oxidase (AOX1) and Bacteroides sartorii co-metabolize the drug Zaleplon, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides vulgatus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Zaleplon Click to Show/Hide the Detail
                                 Drug ID DR1725   Drug Info
                                 Interaction Mechanism Human Aldehyde oxidase (AOX1) and Bacteroides vulgatus co-metabolize the drug Zaleplon, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides xylanisolvens (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Zaleplon Click to Show/Hide the Detail
                                 Drug ID DR1725   Drug Info
                                 Interaction Mechanism Human Aldehyde oxidase (AOX1) and Bacteroides xylanisolvens co-metabolize the drug Zaleplon, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Firmicutes
                  Blautia hansenii (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Zaleplon Click to Show/Hide the Detail
                                 Drug ID DR1725   Drug Info
                                 Interaction Mechanism Human Aldehyde oxidase (AOX1) and Blautia hansenii co-metabolize the drug Zaleplon, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Clostridium botulinum (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Zaleplon Click to Show/Hide the Detail
                                 Drug ID DR1725   Drug Info
                                 Interaction Mechanism Human Aldehyde oxidase (AOX1) and Clostridium botulinum co-metabolize the drug Zaleplon, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Proteobacteria
                  Escherichia coli (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              VUFB-11502 Click to Show/Hide the Detail
                                 Drug ID DR2704   Drug Info
                                 Interaction Mechanism Human Aldehyde oxidase (AOX1) and Escherichia coli co-metabolize the drug VUFB-11502, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [4]
References
1 Characterization of aldehyde oxidase enzyme activity in cryopreserved human hepatocytes. Drug Metab Dispos. 2012 Feb;40(2):267-75.
2 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.
3 The critical role of oxidative stress in the toxicity and metabolism of quinoxaline 1,4-di-N-oxides in vitro and in vivo. Drug Metab Rev. 2016 May;48(2):159-82.
4 Effects of cyadox and olaquindox on intestinal mucosal immunity and on fecal shedding of Escherichia coli in piglets. J Anim Sci. 2006 Sep;84(9):2367-73. Randomized Controlled Trial

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.