Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0054)
DME Name Carboxylesterase 1 (CES1), Homo sapiens DME Info
UniProt ID
EST1_HUMAN
EC Number    EC: 3.1.1.1     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Ester bond hydrolase
Carboxylic ester hydrolase
EC: 3.1.1.1
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Actinobacteria
                  Bifidobacterium ruminatum (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Methylphenidate Click to Show/Hide the Detail
                                 Drug ID DR1054   Drug Info
                                 Interaction Mechanism Human Carboxylesterase 1 (CES1) and Bifidobacterium ruminatum co-metabolize the drug Methylphenidate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Eggerthella lenta (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Methylphenidate Click to Show/Hide the Detail
                                 Drug ID DR1054   Drug Info
                                 Interaction Mechanism Human Carboxylesterase 1 (CES1) and Eggerthella lenta co-metabolize the drug Methylphenidate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Bacteroidetes
                  Bacteroides thetaiotaomicron (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Irinotecan hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0881   Drug Info
                                 Interaction Mechanism Human Carboxylesterase 1 (CES1) metabolizes the drug Irinotecan hydrochloride, and Bacteroides thetaiotaomicron further metabolizes its metabolite (SN-38G), which can indirectly affect efficacy, safety or bioavailability of this drug. [3], [4]
                  Bacteroides uniformis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Irinotecan hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0881   Drug Info
                                 Interaction Mechanism Human Carboxylesterase 1 (CES1) metabolizes the drug Irinotecan hydrochloride, and Bacteroides uniformis further metabolizes its metabolite (SN-38G), which can indirectly affect efficacy, safety or bioavailability of this drug. [3], [4]
                  Bacteroides xylanisolvens (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Enalapril Click to Show/Hide the Detail
                                 Drug ID DR0573   Drug Info
                                 Interaction Mechanism Human Carboxylesterase 1 (CES1) and Bacteroides xylanisolvens co-metabolize the drug Enalapril, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
      Bacteria: Firmicutes
                  Blautia hansenii (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Enalapril Click to Show/Hide the Detail
                                 Drug ID DR0573   Drug Info
                                 Interaction Mechanism Human Carboxylesterase 1 (CES1) and Blautia hansenii co-metabolize the drug Enalapril, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Methylphenidate Click to Show/Hide the Detail
                                 Drug ID DR1054   Drug Info
                                 Interaction Mechanism Human Carboxylesterase 1 (CES1) and Blautia hansenii co-metabolize the drug Methylphenidate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Clostridium botulinum (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Methylphenidate Click to Show/Hide the Detail
                                 Drug ID DR1054   Drug Info
                                 Interaction Mechanism Human Carboxylesterase 1 (CES1) and Clostridium botulinum co-metabolize the drug Methylphenidate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Clostridium perfringens (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Irinotecan hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0881   Drug Info
                                 Interaction Mechanism Human Carboxylesterase 1 (CES1) metabolizes the drug Irinotecan hydrochloride, and Clostridium perfringens further metabolizes its metabolite (SN-38G), which can indirectly affect efficacy, safety or bioavailability of this drug. [3], [6]
                  Holdemanella biformis (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Enalapril Click to Show/Hide the Detail
                                 Drug ID DR0573   Drug Info
                                 Interaction Mechanism Human Carboxylesterase 1 (CES1) and Holdemanella biformis co-metabolize the drug Enalapril, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Lactococcus lactis (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Enalapril Click to Show/Hide the Detail
                                 Drug ID DR0573   Drug Info
                                 Interaction Mechanism Human Carboxylesterase 1 (CES1) and Lactococcus lactis co-metabolize the drug Enalapril, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [7]
                  Streptococcus agalactiae (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Irinotecan hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0881   Drug Info
                                 Interaction Mechanism Human Carboxylesterase 1 (CES1) metabolizes the drug Irinotecan hydrochloride, and Streptococcus agalactiae further metabolizes its metabolite (SN-38G), which can indirectly affect efficacy, safety or bioavailability of this drug. [3], [6]
      Bacteria: Proteobacteria
                  Escherichia coli (enterobacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Irinotecan hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0881   Drug Info
                                 Interaction Mechanism Human Carboxylesterase 1 (CES1) metabolizes the drug Irinotecan hydrochloride, and Escherichia coli further metabolizes its metabolite (SN-38G), which can indirectly affect efficacy, safety or bioavailability of this drug. [3], [8]
                              Irinotecan hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0881   Drug Info
                                 Interaction Mechanism Human Carboxylesterase 1 (CES1) and Escherichia coli co-metabolize the drug Irinotecan hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [8]
References
1 Methylphenidate is stereoselectively hydrolyzed by human carboxylesterase CES1A1. J Pharmacol Exp Ther. 2004 Aug;310(2):469-76.
2 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.
3 Irinotecan and its active metabolite, SN-38: review of bioanalytical methods and recent update from clinical pharmacology perspectives. Biomed Chromatogr. 2010 Jan;24(1):104-23.
4 Three structurally and functionally distinct beta-glucuronidases from the human gut microbe Bacteroides uniformis. J Biol Chem. 2018 Nov 30;293(48):18559-18573.
5 Absorption and cleavage of enalapril, a carboxyl ester prodrug, in the rat intestine: in vitro, in situ intestinal perfusion and portal vein cannulation models. Biopharm Drug Dispos. 2015 Sep;36(6):385-397.
6 Structure and inhibition of microbiome beta-glucuronidases essential to the alleviation of cancer drug toxicity. Chem Biol. 2015 Sep 17;22(9):1238-49.
7 Characterization and kinetic analysis of enzyme-substrate recognition by three recombinant lactococcal PepVs. Arch Biochem Biophys. 2006 Oct 15;454(2):137-45.
8 Involvement of beta-glucuronidase in intestinal microflora in the intestinal toxicity of the antitumor camptothecin derivative irinotecan hydrochloride (CPT-11) in rats. Cancer Res. 1996 Aug 15;56(16):3752-7.

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