General Information of Drug-Metabolizing Enzyme (DME ID: DME0064)
DME Name UDP-glucuronosyltransferase 1A8 (UGT1A8), Homo sapiens DME Info
UniProt ID
UD18_HUMAN
EC Number    EC: 2.4.1.17     (Click to Show/Hide the Complete EC Tree)
Transferase
Glycosyltransferases
Hexosyltransferase
EC: 2.4.1.17
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Proteobacteria
                  Escherichia coli (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Curcumin Click to Show/Hide the Detail
                                 Drug ID DR1941   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A8 (UGT1A8) and Escherichia coli co-metabolize the drug Curcumin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
References
1 Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake. J Biol Chem. 2004 Jan 9;279(2):1429-41.
2 Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism. Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6615-20.

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