| General Information of Drug-Metabolizing Enzyme (DME ID: DME0064) |
| DME Name |
UDP-glucuronosyltransferase 1A8 (UGT1A8), Homo sapiens
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DME Info
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| UniProt ID |
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| EC Number |
EC: 2.4.1.17 (Click to Show/Hide the Complete EC Tree)
Transferase
Glycosyltransferases
Hexosyltransferase
EC: 2.4.1.17
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| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Interactome |
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| Interactions between Microbiome and DME (MICBIO)
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| Bacteria: Proteobacteria |
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| Escherichia coli (enterobacteria) |
Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
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| Curcumin |
Click to Show/Hide the Detail |
| Drug ID |
DR1941
Drug Info
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| Interaction Mechanism |
Human UDP-glucuronosyltransferase 1A8 (UGT1A8) and Escherichia coli co-metabolize the drug Curcumin, which can collectively affect efficacy, safety or bioavailability of this drug. |
[1], [2] |
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| References |
| 1 |
Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake. J Biol Chem. 2004 Jan 9;279(2):1429-41.
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| 2 |
Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism. Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6615-20.
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