Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0071)
DME Name	Cathepsin A (CTSA), Homo sapiens	DME Info
UniProt ID	PPGB_HUMAN
EC Number	EC: 3.4.16.5 (Click to Show/Hide the Complete EC Tree) Hydrolases Peptidase Serine carboxypeptidase EC: 3.4.16.5
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome

Interactions between Microbiome and DME (MICBIO)
Bacteria: Actinobacteria
Gardnerella vaginalis (actinobacteria)		Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
Tenofovir alafenamide		Click to Show/Hide the Detail
Drug ID	DR1552 Drug Info
Interaction Mechanism	Human Cathepsin A (CTSA) and Gardnerella vaginalis co-metabolize the drug Tenofovir alafenamide, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2], [3]
Bacteria: Firmicutes
Lactobacillus crispatus (firmicutes)		Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
Tenofovir alafenamide		Click to Show/Hide the Detail
Drug ID	DR1552 Drug Info
Interaction Mechanism	Human Cathepsin A (CTSA) and Lactobacillus crispatus co-metabolize the drug Tenofovir alafenamide, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]

References
1	Bictegravir/Emtricitabine/Tenofovir Alafenamide: a review in HIV-1 infection. Drugs. 2018 Nov;78(17):1817-1828.
2	Vaginal microbiome modulates topical antiretroviral drug pharmacokinetics. JCI Insight. 2018 Jul 12;3(13). pii: 99545.
3	Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women. Science. 2017 Jun 2;356(6341):938-945.

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