Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0091)
DME Name Prostaglandin G/H synthase 1 (COX-1), Homo sapiens DME Info
UniProt ID
PGH1_HUMAN
EC Number    EC: 1.14.99.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Oxygen paired donor oxidoreductase
EC: 1.14.99.1
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Actinobacteria
                  Bifidobacterium breve (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Bifidobacterium breve co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bifidobacterium ruminatum (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Bifidobacterium ruminatum co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Collinsella intestinalis (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Collinsella intestinalis co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Bacteroidetes
                  Bacteroides caccae (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Bacteroides caccae co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides cellulosilyticus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Bacteroides cellulosilyticus co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides coprophilus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Bacteroides coprophilus co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides dorei (CFB bacteria) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Bacteroides dorei co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Bacteroides dorei co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Voriconazole Click to Show/Hide the Detail
                                 Drug ID DR1709   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Bacteroides dorei co-metabolize the drug Voriconazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides eggerthii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Nateglinide Click to Show/Hide the Detail
                                 Drug ID DR1132   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Bacteroides eggerthii co-metabolize the drug Nateglinide, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides fragilis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Bacteroides fragilis co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Nateglinide Click to Show/Hide the Detail
                                 Drug ID DR1132   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Bacteroides fragilis co-metabolize the drug Nateglinide, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Voriconazole Click to Show/Hide the Detail
                                 Drug ID DR1709   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Bacteroides fragilis co-metabolize the drug Voriconazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides intestinalis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Bacteroides intestinalis co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides sartorii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Bacteroides sartorii co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Nateglinide Click to Show/Hide the Detail
                                 Drug ID DR1132   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Bacteroides sartorii co-metabolize the drug Nateglinide, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Voriconazole Click to Show/Hide the Detail
                                 Drug ID DR1709   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Bacteroides sartorii co-metabolize the drug Voriconazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides thetaiotaomicron (CFB bacteria) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Bacteroides thetaiotaomicron co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Nateglinide Click to Show/Hide the Detail
                                 Drug ID DR1132   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Bacteroides thetaiotaomicron co-metabolize the drug Nateglinide, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Voriconazole Click to Show/Hide the Detail
                                 Drug ID DR1709   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Bacteroides thetaiotaomicron co-metabolize the drug Voriconazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides vulgatus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        5 Drugs Metabolized
                              Imatinib mesylate Click to Show/Hide the Detail
                                 Drug ID DR0858   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Bacteroides vulgatus co-metabolize the drug Imatinib mesylate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Bacteroides vulgatus co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Nateglinide Click to Show/Hide the Detail
                                 Drug ID DR1132   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Bacteroides vulgatus co-metabolize the drug Nateglinide, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Bacteroides vulgatus co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Voriconazole Click to Show/Hide the Detail
                                 Drug ID DR1709   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Bacteroides vulgatus co-metabolize the drug Voriconazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides xylanisolvens (CFB bacteria) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Bacteroides xylanisolvens co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Nateglinide Click to Show/Hide the Detail
                                 Drug ID DR1132   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Bacteroides xylanisolvens co-metabolize the drug Nateglinide, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Voriconazole Click to Show/Hide the Detail
                                 Drug ID DR1709   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Bacteroides xylanisolvens co-metabolize the drug Voriconazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Odoribacter splanchnicus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Odoribacter splanchnicus co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Nateglinide Click to Show/Hide the Detail
                                 Drug ID DR1132   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Odoribacter splanchnicus co-metabolize the drug Nateglinide, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Odoribacter splanchnicus co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Voriconazole Click to Show/Hide the Detail
                                 Drug ID DR1709   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Odoribacter splanchnicus co-metabolize the drug Voriconazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Parabacteroides distasonis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Nateglinide Click to Show/Hide the Detail
                                 Drug ID DR1132   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Parabacteroides distasonis co-metabolize the drug Nateglinide, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Voriconazole Click to Show/Hide the Detail
                                 Drug ID DR1709   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Parabacteroides distasonis co-metabolize the drug Voriconazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Parabacteroides johnsonii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Parabacteroides johnsonii co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Parabacteroides johnsonii co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Parabacteroides merdae (CFB bacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Parabacteroides merdae co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Nateglinide Click to Show/Hide the Detail
                                 Drug ID DR1132   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Parabacteroides merdae co-metabolize the drug Nateglinide, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Prevotella copri (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Prevotella copri co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Firmicutes
                  Anaerobutyricum hallii (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Anaerobutyricum hallii co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Anaerococcus hydrogenalis (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Anaerococcus hydrogenalis co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Anaerostipes hadrus (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Imatinib mesylate Click to Show/Hide the Detail
                                 Drug ID DR0858   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Anaerostipes hadrus co-metabolize the drug Imatinib mesylate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Anaerotruncus colihominis (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Anaerotruncus colihominis co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides pectinophilus (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Bacteroides pectinophilus co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Blautia hansenii (firmicutes) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Blautia hansenii co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Nateglinide Click to Show/Hide the Detail
                                 Drug ID DR1132   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Blautia hansenii co-metabolize the drug Nateglinide, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Blautia hansenii co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Butyrivibrio fibrisolvens (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Alpha-linolenic acid Click to Show/Hide the Detail
                                 Drug ID DR1988   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Butyrivibrio fibrisolvens co-metabolize the drug Alpha-linolenic acid, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [4], [5]
                  Clostridium botulinum (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Nateglinide Click to Show/Hide the Detail
                                 Drug ID DR1132   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Clostridium botulinum co-metabolize the drug Nateglinide, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Clostridium botulinum co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Clostridium scindens (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Clostridium scindens co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Clostridium spiroforme (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Clostridium spiroforme co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Clostridium symbiosum (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Clostridium symbiosum co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Coprococcus comes (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Coprococcus comes co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Dorea formicigenerans (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Dorea formicigenerans co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Enterocloster bolteae (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Enterocloster bolteae co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Eubacterium ventriosum (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Eubacterium ventriosum co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Hungatella hathewayi (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Hungatella hathewayi co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Roseburia intestinalis (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Roseburia intestinalis co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Ruminococcus gnavus (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Ruminococcus gnavus co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Ruminococcus lactaris (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Ruminococcus lactaris co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Proteobacteria
                  Edwardsiella tarda (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Edwardsiella tarda co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Enterobacter cancerogenus (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Enterobacter cancerogenus co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Proteus penneri (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Proteus penneri co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Providencia stuartii (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Providencia stuartii co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Shewanella oneidensis (gamma-proteobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Sulfamethoxazole Click to Show/Hide the Detail
                                 Drug ID DR1511   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Shewanella oneidensis co-metabolize the drug Sulfamethoxazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [6], [7]
      Bacteria: Synergistetes
                  Synergistetes bacterium (synergistetes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Sulfamethoxazole Click to Show/Hide the Detail
                                 Drug ID DR1511   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 1 (COX-1) and Synergistetes bacterium co-metabolize the drug Sulfamethoxazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [8], [9]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.
3 Divergent cyclooxygenase responses to fatty acid structure and peroxide level in fish and mammalian prostaglandin H synthases. FASEB J. 2006 Jun;20(8):1097-108.
4 Immunogenic inhibition of prominent ruminal bacteria as a means to reduce lipolysis and biohydrogenation activity in vitro. Food Chem. 2017 Mar 1;218:372-377.
5 Cell-associated alpha-amylases of butyrate-producing Firmicute bacteria from the human colon. Microbiology. 2006 Nov;152(Pt 11):3281-3290.
6 Biodegradation of sulfonamides by Shewanella oneidensis MR-1 and Shewanella sp. strain MR-4. Biodegradation. 2018 Apr;29(2):129-140.
7 The 285 kDa Bap/RTX hybrid cell surface protein (SO4317) of Shewanella oneidensis MR-1 is a key mediator of biofilm formation. Res Microbiol. 2010 Mar;161(2):144-52.
8 Bacterial community changes and antibiotic resistance gene quantification in microbial electrolysis cells during long-term sulfamethoxazole treatment. Bioresour Technol. 2019 Dec;294:122170.
9 Distributions of Synergistetes in clinically-healthy and diseased periodontal and peri-implant niches. Microb Pathog. 2016 May;94:90-103.

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