Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0092)
DME Name	Thymidine phosphorylase (TYMP), Homo sapiens	DME Info
UniProt ID	TYPH_HUMAN
EC Number	EC: 2.4.2.4 (Click to Show/Hide the Complete EC Tree) Transferase Glycosyltransferases Pentosyltransferase EC: 2.4.2.4
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome

Interactions between Microbiome and DME (MICBIO)
Bacteria: Actinobacteria
Collinsella aerofaciens (actinobacteria)		Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
Capecitabine		Click to Show/Hide the Detail
Drug ID	DR0266 Drug Info
Interaction Mechanism	Human Thymidine phosphorylase (TYMP) and Collinsella aerofaciens co-metabolize the drug Capecitabine, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Bacteria: Proteobacteria
Salmonella enterica (enterobacteria)		Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
Capecitabine		Click to Show/Hide the Detail
Drug ID	DR0266 Drug Info
Interaction Mechanism	Human Thymidine phosphorylase (TYMP) and Salmonella enterica co-metabolize the drug Capecitabine, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]

References
1	Induction of thymidine phosphorylase in both irradiated and shielded, contralateral human U87MG glioma xenografts: implications for a dual modality treatment using capecitabine and irradiation. Mol Cancer Ther. 2002 Oct;1(12):1139-45.
2	Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.

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