| General Information of Drug-Metabolizing Enzyme (DME ID: DME0093) |
| DME Name |
Glutathione S-transferase theta-1 (GSTT1), Homo sapiens
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DME Info
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| UniProt ID |
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| EC Number |
EC: 2.5.1.18 (Click to Show/Hide the Complete EC Tree)
Transferase
Alkyl/aryl transferase
Alkyl/aryl transferase
EC: 2.5.1.18
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| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Interactome |
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| Interactions between Microbiome and DME (MICBIO)
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| Bacteria: Bacteroidetes |
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| Prevotella copri (CFB bacteria) |
Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
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| Carboplatin |
Click to Show/Hide the Detail |
| Drug ID |
DR0272
Drug Info
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| Interaction Mechanism |
Human Glutathione S-transferase theta-1 (GSTT1) and Prevotella copri co-metabolize the drug Carboplatin, which can collectively affect efficacy, safety or bioavailability of this drug. |
[1], [2] |
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| References |
| 1 |
PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA150642262)
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| 2 |
revotella copri is associated with carboplatin-induced gut toxicity. Cell Death Dis. 2019 Sep 26;10(10):714.
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