Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0095)
DME Name Metallothionein-2A (MT2A), Homo sapiens DME Info
UniProt ID
MT2_HUMAN
EC Number    EC: 1.8.5.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Sulfur donor oxidoreductase
Quinone acceptor oxidoreductase
EC: 1.8.5.1
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Bacteroidetes
                  Prevotella copri (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Carboplatin Click to Show/Hide the Detail
                                 Drug ID DR0272   Drug Info
                                 Interaction Mechanism Human Metallothionein-2A (MT2A) and Prevotella copri co-metabolize the drug Carboplatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
References
1 PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA150642262)
2 revotella copri is associated with carboplatin-induced gut toxicity. Cell Death Dis. 2019 Sep 26;10(10):714.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.