Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0100)
DME Name Vitamin D 25-hydroxylase (CYP2R1), Homo sapiens DME Info
UniProt ID
CP2R1_HUMAN
EC Number    EC: 1.14.14.24     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Flavin/flavoprotein donor oxidoreductase
EC: 1.14.14.24
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Actinobacteria
                  Mycobacterium tuberculosis (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Vitamin D Click to Show/Hide the Detail
                                 Drug ID DR1700   Drug Info
                                 Interaction Mechanism Human Vitamin D 25-hydroxylase (CYP2R1) and Mycobacterium tuberculosis co-metabolize the drug Vitamin D, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
References
1 Placental vitamin D metabolism and its associations with circulating vitamin D metabolites in pregnant women. Am J Clin Nutr. 2017 Dec;106(6):1439-1448.
2 Identification of Mycobacterium tuberculosis enzyme involved in vitamin D and 7-dehydrocholesterol metabolism. J Steroid Biochem Mol Biol. 2017 May;169:202-209.

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