General Information of Drug-Metabolizing Enzyme (DME ID: DME0111)
DME Name Ecto-5'-nucleotidase (NT5E), Homo sapiens DME Info
UniProt ID
5NTD_HUMAN
EC Number    EC: 3.1.3.5     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Ester bond hydrolase
Phosphoric monoester hydrolase
EC: 3.1.3.5
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Tenericutes
                  Mycoplasma hyorhinis (mycoplasmas) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Cytarabine Click to Show/Hide the Detail
                                 Drug ID DR0398   Drug Info
                                 Interaction Mechanism Human Ecto-5'-nucleotidase (NT5E) and Mycoplasma hyorhinis co-metabolize the drug Cytarabine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
References
1 Genetic factors influencing cytarabine therapy. Pharmacogenomics. 2009 Oct;10(10):1657-74.
2 Mycoplasma hyorhinis-encoded cytidine deaminase efficiently inactivates cytosine-based anticancer drugs. FEBS Open Bio. 2015 Aug 3;5:634-9.

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