| General Information of Drug-Metabolizing Enzyme (DME ID: DME0111) |
| DME Name |
Ecto-5'-nucleotidase (NT5E), Homo sapiens
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DME Info
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| UniProt ID |
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| EC Number |
EC: 3.1.3.5 (Click to Show/Hide the Complete EC Tree)
Hydrolases
Ester bond hydrolase
Phosphoric monoester hydrolase
EC: 3.1.3.5
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| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Interactome |
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| Interactions between Microbiome and DME (MICBIO)
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| Bacteria: Tenericutes |
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| Mycoplasma hyorhinis (mycoplasmas) |
Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
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| Cytarabine |
Click to Show/Hide the Detail |
| Drug ID |
DR0398
Drug Info
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| Interaction Mechanism |
Human Ecto-5'-nucleotidase (NT5E) and Mycoplasma hyorhinis co-metabolize the drug Cytarabine, which can collectively affect efficacy, safety or bioavailability of this drug. |
[1], [2] |
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| References |
| 1 |
Genetic factors influencing cytarabine therapy. Pharmacogenomics. 2009 Oct;10(10):1657-74.
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| 2 |
Mycoplasma hyorhinis-encoded cytidine deaminase efficiently inactivates cytosine-based anticancer drugs. FEBS Open Bio. 2015 Aug 3;5:634-9.
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